Abstract
An efficient synthesis of the O-linked glycosylamino acid Fmoc-l-Ser((Ac)3-β-d-GlcNAc)-OH building block is described. The utility of the method was demonstrated with direct solid-phase O-glycosylation of the hydroxyl group on the amino acid (Ser) side chain of a human A crystallin-derived peptide (AIPVSREEK) in nearly quantitative glycosylation yield.
Original language | English |
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Pages (from-to) | 1151-1157 |
Number of pages | 7 |
Journal | Australian Journal of Chemistry |
Volume | 70 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2017 |