An efficient synthesis of the O-linked glycosylamino acid Fmoc-l-Ser((Ac)3-β-d-GlcNAc)-OH building block is described. The utility of the method was demonstrated with direct solid-phase O-glycosylation of the hydroxyl group on the amino acid (Ser) side chain of a human A crystallin-derived peptide (AIPVSREEK) in nearly quantitative glycosylation yield.
|Number of pages||7|
|Journal||Australian Journal of Chemistry|
|Publication status||Published - 2017|