Whilst many medical educators engage in international activities (such as conferences or projects), working internationally on a limited basis or more permanently will generally require adapting to different cultures and contexts. In some instances, this might be difficult. When considering working internationally, there are a number of personal and professional considerations. Personal considerations include motivation for wanting to work abroad, values and beliefs, the practicalities, as well as family involvement. Professional considerations include maintaining professional registration and adapting to different institutional work patterns and expectations, cultures and hierarchies. This article provides guidance for medical educators who are considering working in other countries and regions.