Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study

Kathleen Gali, Heike Spaderna, Jacqueline M A Smits, Katrina A Bramstedt, Gerdi Weidner

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

OBJECTIVE 

We examined the association of smoking status at time of listing with waitlist mortality among heart transplant (HTx) candidates.

PARTICIPANTS AND DESIGN

Data were analyzed from 316 participants (aged 53 ± 11; 18% female) of the Waiting for a New Heart Study, a prospective observational study of patients newly listed for HTx at 17 hospitals.

RESULTS

During the study period (April 2005 to March 2010), 14% of those who never smoked died, 18% among former smokers died, and almost half (42%) died among those who reported smoking at time of wait listing. Multivariate Cox regression models controlling for age, sex, and disease severity revealed smoking at time of listing was associated with significantly higher risk of mortality compared to never smoking (hazard ratio [HR] = 3.43; P = .03). The relationship between smoking and mortality risk appeared to follow a dose-dependent pattern: adjusted HRs were 1.80 for those who quit ≤1 year ago, 1.25 for those who quit >1 to 10 years ago, and 0.90 for those quit >10 years ago, compared to never smokers. Smoking at time of listing may increase risk of mortality during the waiting period, indicating the need for improved strategies to achieve smoking cessation as early as possible in the course of HTx.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalProgress in Transplantation
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Jun 2016

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Waiting Lists
Observational Studies
Smoking
Prospective Studies
Transplants
Mortality
Smoking Cessation
Proportional Hazards Models

Cite this

Gali, Kathleen ; Spaderna, Heike ; Smits, Jacqueline M A ; Bramstedt, Katrina A ; Weidner, Gerdi. / Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study. In: Progress in Transplantation. 2016 ; Vol. 26, No. 2. pp. 117-121.
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Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study. / Gali, Kathleen; Spaderna, Heike; Smits, Jacqueline M A; Bramstedt, Katrina A; Weidner, Gerdi.

In: Progress in Transplantation, Vol. 26, No. 2, 01.06.2016, p. 117-121.

Research output: Contribution to journalArticleResearchpeer-review

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