Single nucleotide polymorphisms (SNPs)

Jyotsna Batra; Srilakshmi Srinivasan; Judith Clements

doi:10.1007/978-1-4899-8050-2_5

Single nucleotide polymorphisms (SNPs)

Jyotsna Batra, Srilakshmi Srinivasan, Judith Clements^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Abstract

Single nucleotide polymorphisms (SNPs) have been suggested as a useful tool for dissecting various human complex disorders, classically at a small scale and recently at large genome-wide levels. The advent of new technologies, including chip-based genotyping as well as high-throughput next generation sequencing, has opened new avenues for SNPs to be used in clinical practice. In this chapter, we summarize the current use of SNPs mainly SNP-based arrays in various clinical applications as well as describe the classical and recent methods of SNP detection and genotyping currently being used in the research and clinical environments.

Original language	English
Title of host publication	Molecular Testing in Cancer
Publisher	Springer
Pages	55-80
Number of pages	26
ISBN (Electronic)	9781489980502
ISBN (Print)	9781489980496
DOIs	https://doi.org/10.1007/978-1-4899-8050-2_5
Publication status	Published - 1 Oct 2014
Externally published	Yes

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10.1007/978-1-4899-8050-2_5

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Single nucleotide polymorphisms (SNPs)

Abstract

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