Simultaneous monitoring of vascular contractility, intracellular pH and intracellular calcium in isolated rat mesenteric arteries; effects of weak bases

Donna Otter, Clare Austin*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

We report the first simultaneous measurements of pH(i), [Ca2+](i) and tension, upon alteration of pH(i), in isolated rat mesenteric arteries loaded with both carboxy SNARF and indo-1. In these vessels (pre-contracted by 30 mM KCI) alterations of pH(i), by addition and subsequent washout of weak bases, produced complicated effects on tone. Although the changes in contractility did not mirror the changes in pH(i) they were, at all times, accompanied by parallel changes in [Ca2+](i).

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalExperimental Physiology
Volume85
Issue number3
DOIs
Publication statusPublished - May 2000
Externally publishedYes

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