Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort study

Xiaolin Xu; Gita D. Mishra; Annette J. Dobson; Mark Jones

doi:10.1038/s41366-018-0250-7

Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort study

Xiaolin Xu^*, Gita D. Mishra, Annette J. Dobson, Mark Jones

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

BACKGROUND/OBJECTIVES: Although weight change has been studied in relation to many individual chronic conditions, limited studies have focused on weight change and multimorbidity. This study examines the relationship between short-term weight change and the accumulation of multimorbidity in midlife.

METHODS: We used data from 7357 women aged 45-50 years without a history of any chronic conditions. The women were surveyed approximately every 3 years from 1996 to 2016. Associations between short-term weight change and accumulation of multimorbidity (two or more of nine chronic conditions) over each 3-year period, adjusting for baseline body mass index (BMI) or time-varying BMI (3-year period), were examined using repeated measures models. Short-term weight change was categorised into seven groups of annual weight change from high weight loss ( ≤ -5%) to high weight gain (> + 5%).

RESULTS: Over 20 years, 60.4% (n = 4442) of women developed multimorbidity. Baseline BMI, time-varying BMI and short-term weight gain were all associated with the accumulation of multimorbidity. After controlling for sociodemographic, lifestyle factors and menopausal status, high weight gain was associated with a 25% increased odds of multimorbidity (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.08-1.45) compared with maintaining a stable weight. The results were consistent among models adjusting for baseline BMI (OR 1.24, 95% CI 1.07-1.44) or time-varying BMI (OR 1.34, 95% CI 1.16-1.54). Weight loss was associated with increased odds of multimorbidity in women with normal BMI (baseline or time-varying).

CONCLUSIONS: Short-term weight gain is associated with significantly increased odds of multimorbidity in mid-aged women. This association is independent from baseline BMI (at 45-50 years) and time-varying BMI. These findings support a persistent weight management regime and prevention of weight gain throughout women's midlife.

Original language	English
Pages (from-to)	1811-1821
Number of pages	11
Journal	International Journal of Obesity
Volume	43
Issue number	9
Early online date	20 Nov 2018
DOIs	https://doi.org/10.1038/s41366-018-0250-7
Publication status	Published - 1 Sept 2019
Externally published	Yes

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10.1038/s41366-018-0250-7

Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort studyAccepted author manuscript, 1.67 MBLicence: Other

Cite this

@article{e55a79d20f034bd6a0e9e94dd7e0e68a,

title = "Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort study",

abstract = "BACKGROUND/OBJECTIVES: Although weight change has been studied in relation to many individual chronic conditions, limited studies have focused on weight change and multimorbidity. This study examines the relationship between short-term weight change and the accumulation of multimorbidity in midlife.METHODS: We used data from 7357 women aged 45-50 years without a history of any chronic conditions. The women were surveyed approximately every 3 years from 1996 to 2016. Associations between short-term weight change and accumulation of multimorbidity (two or more of nine chronic conditions) over each 3-year period, adjusting for baseline body mass index (BMI) or time-varying BMI (3-year period), were examined using repeated measures models. Short-term weight change was categorised into seven groups of annual weight change from high weight loss ( ≤ -5%) to high weight gain (> + 5%).RESULTS: Over 20 years, 60.4% (n = 4442) of women developed multimorbidity. Baseline BMI, time-varying BMI and short-term weight gain were all associated with the accumulation of multimorbidity. After controlling for sociodemographic, lifestyle factors and menopausal status, high weight gain was associated with a 25% increased odds of multimorbidity (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.08-1.45) compared with maintaining a stable weight. The results were consistent among models adjusting for baseline BMI (OR 1.24, 95% CI 1.07-1.44) or time-varying BMI (OR 1.34, 95% CI 1.16-1.54). Weight loss was associated with increased odds of multimorbidity in women with normal BMI (baseline or time-varying).CONCLUSIONS: Short-term weight gain is associated with significantly increased odds of multimorbidity in mid-aged women. This association is independent from baseline BMI (at 45-50 years) and time-varying BMI. These findings support a persistent weight management regime and prevention of weight gain throughout women's midlife.",

author = "Xiaolin Xu and Mishra, {Gita D.} and Dobson, {Annette J.} and Mark Jones",

year = "2019",

month = sep,

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doi = "10.1038/s41366-018-0250-7",

language = "English",

volume = "43",

pages = "1811--1821",

journal = "International Journal of Obesity",

issn = "0307-0565",

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TY - JOUR

T1 - Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort study

AU - Xu, Xiaolin

AU - Mishra, Gita D.

AU - Dobson, Annette J.

AU - Jones, Mark

PY - 2019/9/1

Y1 - 2019/9/1

N2 - BACKGROUND/OBJECTIVES: Although weight change has been studied in relation to many individual chronic conditions, limited studies have focused on weight change and multimorbidity. This study examines the relationship between short-term weight change and the accumulation of multimorbidity in midlife.METHODS: We used data from 7357 women aged 45-50 years without a history of any chronic conditions. The women were surveyed approximately every 3 years from 1996 to 2016. Associations between short-term weight change and accumulation of multimorbidity (two or more of nine chronic conditions) over each 3-year period, adjusting for baseline body mass index (BMI) or time-varying BMI (3-year period), were examined using repeated measures models. Short-term weight change was categorised into seven groups of annual weight change from high weight loss ( ≤ -5%) to high weight gain (> + 5%).RESULTS: Over 20 years, 60.4% (n = 4442) of women developed multimorbidity. Baseline BMI, time-varying BMI and short-term weight gain were all associated with the accumulation of multimorbidity. After controlling for sociodemographic, lifestyle factors and menopausal status, high weight gain was associated with a 25% increased odds of multimorbidity (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.08-1.45) compared with maintaining a stable weight. The results were consistent among models adjusting for baseline BMI (OR 1.24, 95% CI 1.07-1.44) or time-varying BMI (OR 1.34, 95% CI 1.16-1.54). Weight loss was associated with increased odds of multimorbidity in women with normal BMI (baseline or time-varying).CONCLUSIONS: Short-term weight gain is associated with significantly increased odds of multimorbidity in mid-aged women. This association is independent from baseline BMI (at 45-50 years) and time-varying BMI. These findings support a persistent weight management regime and prevention of weight gain throughout women's midlife.

AB - BACKGROUND/OBJECTIVES: Although weight change has been studied in relation to many individual chronic conditions, limited studies have focused on weight change and multimorbidity. This study examines the relationship between short-term weight change and the accumulation of multimorbidity in midlife.METHODS: We used data from 7357 women aged 45-50 years without a history of any chronic conditions. The women were surveyed approximately every 3 years from 1996 to 2016. Associations between short-term weight change and accumulation of multimorbidity (two or more of nine chronic conditions) over each 3-year period, adjusting for baseline body mass index (BMI) or time-varying BMI (3-year period), were examined using repeated measures models. Short-term weight change was categorised into seven groups of annual weight change from high weight loss ( ≤ -5%) to high weight gain (> + 5%).RESULTS: Over 20 years, 60.4% (n = 4442) of women developed multimorbidity. Baseline BMI, time-varying BMI and short-term weight gain were all associated with the accumulation of multimorbidity. After controlling for sociodemographic, lifestyle factors and menopausal status, high weight gain was associated with a 25% increased odds of multimorbidity (odds ratio (OR) 1.25, 95% confidence interval (CI) 1.08-1.45) compared with maintaining a stable weight. The results were consistent among models adjusting for baseline BMI (OR 1.24, 95% CI 1.07-1.44) or time-varying BMI (OR 1.34, 95% CI 1.16-1.54). Weight loss was associated with increased odds of multimorbidity in women with normal BMI (baseline or time-varying).CONCLUSIONS: Short-term weight gain is associated with significantly increased odds of multimorbidity in mid-aged women. This association is independent from baseline BMI (at 45-50 years) and time-varying BMI. These findings support a persistent weight management regime and prevention of weight gain throughout women's midlife.

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U2 - 10.1038/s41366-018-0250-7

DO - 10.1038/s41366-018-0250-7

M3 - Article

C2 - 30459401

AN - SCOPUS:85057050547

SN - 0307-0565

VL - 43

SP - 1811

EP - 1821

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 9

ER -

Short-term weight gain is associated with accumulation of multimorbidity in mid-aged women: a 20-year cohort study

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