Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study

Elisabeth Isenring, Laisa Teleni, Richard John Woodman, Michael G Kimlin, Euan Walpole, Christos Stelios Karapetis, Shawgi Sukumaran, Ganessan Kichenadasse, Skye Marshall, Bogda Koczwara

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Abstract

Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. Methods and Study Design: A 12-week prospective cohort study was conducted in chemotherapy-naïve patients in two Australian locations with different sun exposure. Vitamin D deficiency was defined as ≤ 25 nmol/L and insufficiency 26-50 nmol/L 25(OH) D. Demographics, chemotherapy regimen, nutritional status, sun exposure, geographic location, and sea-son were collected at baseline, 6 and 12 weeks after commencing chemotherapy. Results: Eighty-five patients (μ55.3±13.4 years of age; 49% female) were recruited, 96% Caucasian. Fifty-four patients were treated with cura-tive intent (mostly for breast [n=29] or colorectal [n=12] cancers). At baseline, 10 patients were vitamin D defi-cient and 33 were insufficient. Mean serum 25(OH) D (nmol/L) was higher at latitude -27.5o (Brisbane) than lati-tude -34.9o (Adelaide) (μ61.9±22.1 vs μ42.2±19.2, p < 0.001) and varied according to season (spring: μ46.9±20.3, summer: μ50.8±18.2, autumn: μ76.4±25.2, winter: μ36.5±15.7, p < 0.001). Serum 25(OH) D decreased with chemotherapy (baseline: μ49.2±22.3, 6-weeks: μ40.9±19.0, 12-weeks: μ45.9±19.7, p=0.05), with a significant and more rapid decline in winter and autumn (p=0.03). Conclusions: Chemotherapy is associated with a decrease in serum vitamin D, particularly during winter and autumn. Investigations into the underlying mechanism and as-sociated potential outcomes with this decrease requires further investigation.

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalAsia Pacific Journal of Clinical Nutrition
Volume27
Issue number5
Early online date1 Apr 2018
DOIs
Publication statusPublished - 1 Sep 2018

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Vitamin D
Cohort Studies
Prospective Studies
Drug Therapy
Serum
Solar System
Vitamin D Deficiency
Geographic Locations
compound A 12
Nutritional Status
Nuclear Family
Oceans and Seas
Muscle Cells
Fatigue
Breast
Demography
Bone and Bones
Neoplasms

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Isenring, E., Teleni, L., Woodman, R. J., Kimlin, M. G., Walpole, E., Karapetis, C. S., ... Koczwara, B. (2018). Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study. Asia Pacific Journal of Clinical Nutrition, 27(5), 962-967. https://doi.org/10.6133/apjcn.042018.01
Isenring, Elisabeth ; Teleni, Laisa ; Woodman, Richard John ; Kimlin, Michael G ; Walpole, Euan ; Karapetis, Christos Stelios ; Sukumaran, Shawgi ; Kichenadasse, Ganessan ; Marshall, Skye ; Koczwara, Bogda. / Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study. In: Asia Pacific Journal of Clinical Nutrition. 2018 ; Vol. 27, No. 5. pp. 962-967.
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title = "Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study",
abstract = "Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. Methods and Study Design: A 12-week prospective cohort study was conducted in chemotherapy-na{\"i}ve patients in two Australian locations with different sun exposure. Vitamin D deficiency was defined as ≤ 25 nmol/L and insufficiency 26-50 nmol/L 25(OH) D. Demographics, chemotherapy regimen, nutritional status, sun exposure, geographic location, and sea-son were collected at baseline, 6 and 12 weeks after commencing chemotherapy. Results: Eighty-five patients (μ55.3±13.4 years of age; 49{\%} female) were recruited, 96{\%} Caucasian. Fifty-four patients were treated with cura-tive intent (mostly for breast [n=29] or colorectal [n=12] cancers). At baseline, 10 patients were vitamin D defi-cient and 33 were insufficient. Mean serum 25(OH) D (nmol/L) was higher at latitude -27.5o (Brisbane) than lati-tude -34.9o (Adelaide) (μ61.9±22.1 vs μ42.2±19.2, p < 0.001) and varied according to season (spring: μ46.9±20.3, summer: μ50.8±18.2, autumn: μ76.4±25.2, winter: μ36.5±15.7, p < 0.001). Serum 25(OH) D decreased with chemotherapy (baseline: μ49.2±22.3, 6-weeks: μ40.9±19.0, 12-weeks: μ45.9±19.7, p=0.05), with a significant and more rapid decline in winter and autumn (p=0.03). Conclusions: Chemotherapy is associated with a decrease in serum vitamin D, particularly during winter and autumn. Investigations into the underlying mechanism and as-sociated potential outcomes with this decrease requires further investigation.",
author = "Elisabeth Isenring and Laisa Teleni and Woodman, {Richard John} and Kimlin, {Michael G} and Euan Walpole and Karapetis, {Christos Stelios} and Shawgi Sukumaran and Ganessan Kichenadasse and Skye Marshall and Bogda Koczwara",
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Isenring, E, Teleni, L, Woodman, RJ, Kimlin, MG, Walpole, E, Karapetis, CS, Sukumaran, S, Kichenadasse, G, Marshall, S & Koczwara, B 2018, 'Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study' Asia Pacific Journal of Clinical Nutrition, vol. 27, no. 5, pp. 962-967. https://doi.org/10.6133/apjcn.042018.01

Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study. / Isenring, Elisabeth; Teleni, Laisa; Woodman, Richard John; Kimlin, Michael G; Walpole, Euan; Karapetis, Christos Stelios; Sukumaran, Shawgi; Kichenadasse, Ganessan; Marshall, Skye; Koczwara, Bogda.

In: Asia Pacific Journal of Clinical Nutrition, Vol. 27, No. 5, 01.09.2018, p. 962-967.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study

AU - Isenring, Elisabeth

AU - Teleni, Laisa

AU - Woodman, Richard John

AU - Kimlin, Michael G

AU - Walpole, Euan

AU - Karapetis, Christos Stelios

AU - Sukumaran, Shawgi

AU - Kichenadasse, Ganessan

AU - Marshall, Skye

AU - Koczwara, Bogda

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. Methods and Study Design: A 12-week prospective cohort study was conducted in chemotherapy-naïve patients in two Australian locations with different sun exposure. Vitamin D deficiency was defined as ≤ 25 nmol/L and insufficiency 26-50 nmol/L 25(OH) D. Demographics, chemotherapy regimen, nutritional status, sun exposure, geographic location, and sea-son were collected at baseline, 6 and 12 weeks after commencing chemotherapy. Results: Eighty-five patients (μ55.3±13.4 years of age; 49% female) were recruited, 96% Caucasian. Fifty-four patients were treated with cura-tive intent (mostly for breast [n=29] or colorectal [n=12] cancers). At baseline, 10 patients were vitamin D defi-cient and 33 were insufficient. Mean serum 25(OH) D (nmol/L) was higher at latitude -27.5o (Brisbane) than lati-tude -34.9o (Adelaide) (μ61.9±22.1 vs μ42.2±19.2, p < 0.001) and varied according to season (spring: μ46.9±20.3, summer: μ50.8±18.2, autumn: μ76.4±25.2, winter: μ36.5±15.7, p < 0.001). Serum 25(OH) D decreased with chemotherapy (baseline: μ49.2±22.3, 6-weeks: μ40.9±19.0, 12-weeks: μ45.9±19.7, p=0.05), with a significant and more rapid decline in winter and autumn (p=0.03). Conclusions: Chemotherapy is associated with a decrease in serum vitamin D, particularly during winter and autumn. Investigations into the underlying mechanism and as-sociated potential outcomes with this decrease requires further investigation.

AB - Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. Methods and Study Design: A 12-week prospective cohort study was conducted in chemotherapy-naïve patients in two Australian locations with different sun exposure. Vitamin D deficiency was defined as ≤ 25 nmol/L and insufficiency 26-50 nmol/L 25(OH) D. Demographics, chemotherapy regimen, nutritional status, sun exposure, geographic location, and sea-son were collected at baseline, 6 and 12 weeks after commencing chemotherapy. Results: Eighty-five patients (μ55.3±13.4 years of age; 49% female) were recruited, 96% Caucasian. Fifty-four patients were treated with cura-tive intent (mostly for breast [n=29] or colorectal [n=12] cancers). At baseline, 10 patients were vitamin D defi-cient and 33 were insufficient. Mean serum 25(OH) D (nmol/L) was higher at latitude -27.5o (Brisbane) than lati-tude -34.9o (Adelaide) (μ61.9±22.1 vs μ42.2±19.2, p < 0.001) and varied according to season (spring: μ46.9±20.3, summer: μ50.8±18.2, autumn: μ76.4±25.2, winter: μ36.5±15.7, p < 0.001). Serum 25(OH) D decreased with chemotherapy (baseline: μ49.2±22.3, 6-weeks: μ40.9±19.0, 12-weeks: μ45.9±19.7, p=0.05), with a significant and more rapid decline in winter and autumn (p=0.03). Conclusions: Chemotherapy is associated with a decrease in serum vitamin D, particularly during winter and autumn. Investigations into the underlying mechanism and as-sociated potential outcomes with this decrease requires further investigation.

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DO - 10.6133/apjcn.042018.01

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JO - Asia Pacific Journal of Clinical Nutrition

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