Self-crimping, biodegradable, electrospun polymer microfibers

Denver C Surrao, James W S Hayami, Stephen D Waldman, Brian G Amsden

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

Semicrystalline poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) was used to produce electrospun fibers with diameters on the subcellular scale. P(LLA-CL) was chosen because it is biocompatible and its chemical and physical properties are easily tunable. The use of a rotating wire mandrel as a collection device in the electrospinning process, along with high collection speeds, was used to align electrospun fibers. Upon removal of the fibers from the mandrel, the fibers shrunk in length, producing a crimp pattern characteristic of collagen fibrils in soft connective tissues. The crimping effect was determined to be a result of the residual stresses resident in the fibers due to the fiber alignment process and the difference between the operating temperature (T(op)) and the glass-transition temperature (T(g)) of the polymer. The electrospun fibers could be induced to crimp by adjusting the operating temperature to be greater than that of the polymer glass-transition temperature. Moreover, the crimped fibers exhibited a toe region in their stress-strain profile that is characteristic of collagen present in tendons and ligaments. The crimp pattern was retained during in vitro degradation over 4 weeks. Primary bovine fibroblasts seeded onto these crimped fibers attached, proliferated, and deposited extracellular matrix (ECM) molecules on the surface of the fiber mats. These self-crimping fibers hold great promise for use in tissue engineering scaffolds for connective tissues that require fibers similar in structure to that of crimped collagen fibrils.

Original languageEnglish
Pages (from-to)3624-9
Number of pages6
JournalBiomacromolecules
Volume11
Issue number12
DOIs
Publication statusPublished - 13 Dec 2010
Externally publishedYes

Fingerprint

Biodegradable polymers
Fibers
Collagen
Polymers
Tissue
Tissue Scaffolds
Ligaments
Tendons
Electrospinning
Fibroblasts
Scaffolds (biology)
Tissue engineering
Chemical properties
Residual stresses
Physical properties

Cite this

Surrao, D. C., Hayami, J. W. S., Waldman, S. D., & Amsden, B. G. (2010). Self-crimping, biodegradable, electrospun polymer microfibers. Biomacromolecules, 11(12), 3624-9. https://doi.org/10.1021/bm101078c
Surrao, Denver C ; Hayami, James W S ; Waldman, Stephen D ; Amsden, Brian G. / Self-crimping, biodegradable, electrospun polymer microfibers. In: Biomacromolecules. 2010 ; Vol. 11, No. 12. pp. 3624-9.
@article{0d2f891773c046d29c8d784f03fdba0a,
title = "Self-crimping, biodegradable, electrospun polymer microfibers",
abstract = "Semicrystalline poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) was used to produce electrospun fibers with diameters on the subcellular scale. P(LLA-CL) was chosen because it is biocompatible and its chemical and physical properties are easily tunable. The use of a rotating wire mandrel as a collection device in the electrospinning process, along with high collection speeds, was used to align electrospun fibers. Upon removal of the fibers from the mandrel, the fibers shrunk in length, producing a crimp pattern characteristic of collagen fibrils in soft connective tissues. The crimping effect was determined to be a result of the residual stresses resident in the fibers due to the fiber alignment process and the difference between the operating temperature (T(op)) and the glass-transition temperature (T(g)) of the polymer. The electrospun fibers could be induced to crimp by adjusting the operating temperature to be greater than that of the polymer glass-transition temperature. Moreover, the crimped fibers exhibited a toe region in their stress-strain profile that is characteristic of collagen present in tendons and ligaments. The crimp pattern was retained during in vitro degradation over 4 weeks. Primary bovine fibroblasts seeded onto these crimped fibers attached, proliferated, and deposited extracellular matrix (ECM) molecules on the surface of the fiber mats. These self-crimping fibers hold great promise for use in tissue engineering scaffolds for connective tissues that require fibers similar in structure to that of crimped collagen fibrils.",
author = "Surrao, {Denver C} and Hayami, {James W S} and Waldman, {Stephen D} and Amsden, {Brian G}",
year = "2010",
month = "12",
day = "13",
doi = "10.1021/bm101078c",
language = "English",
volume = "11",
pages = "3624--9",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "12",

}

Surrao, DC, Hayami, JWS, Waldman, SD & Amsden, BG 2010, 'Self-crimping, biodegradable, electrospun polymer microfibers' Biomacromolecules, vol. 11, no. 12, pp. 3624-9. https://doi.org/10.1021/bm101078c

Self-crimping, biodegradable, electrospun polymer microfibers. / Surrao, Denver C; Hayami, James W S; Waldman, Stephen D; Amsden, Brian G.

In: Biomacromolecules, Vol. 11, No. 12, 13.12.2010, p. 3624-9.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Self-crimping, biodegradable, electrospun polymer microfibers

AU - Surrao, Denver C

AU - Hayami, James W S

AU - Waldman, Stephen D

AU - Amsden, Brian G

PY - 2010/12/13

Y1 - 2010/12/13

N2 - Semicrystalline poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) was used to produce electrospun fibers with diameters on the subcellular scale. P(LLA-CL) was chosen because it is biocompatible and its chemical and physical properties are easily tunable. The use of a rotating wire mandrel as a collection device in the electrospinning process, along with high collection speeds, was used to align electrospun fibers. Upon removal of the fibers from the mandrel, the fibers shrunk in length, producing a crimp pattern characteristic of collagen fibrils in soft connective tissues. The crimping effect was determined to be a result of the residual stresses resident in the fibers due to the fiber alignment process and the difference between the operating temperature (T(op)) and the glass-transition temperature (T(g)) of the polymer. The electrospun fibers could be induced to crimp by adjusting the operating temperature to be greater than that of the polymer glass-transition temperature. Moreover, the crimped fibers exhibited a toe region in their stress-strain profile that is characteristic of collagen present in tendons and ligaments. The crimp pattern was retained during in vitro degradation over 4 weeks. Primary bovine fibroblasts seeded onto these crimped fibers attached, proliferated, and deposited extracellular matrix (ECM) molecules on the surface of the fiber mats. These self-crimping fibers hold great promise for use in tissue engineering scaffolds for connective tissues that require fibers similar in structure to that of crimped collagen fibrils.

AB - Semicrystalline poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) was used to produce electrospun fibers with diameters on the subcellular scale. P(LLA-CL) was chosen because it is biocompatible and its chemical and physical properties are easily tunable. The use of a rotating wire mandrel as a collection device in the electrospinning process, along with high collection speeds, was used to align electrospun fibers. Upon removal of the fibers from the mandrel, the fibers shrunk in length, producing a crimp pattern characteristic of collagen fibrils in soft connective tissues. The crimping effect was determined to be a result of the residual stresses resident in the fibers due to the fiber alignment process and the difference between the operating temperature (T(op)) and the glass-transition temperature (T(g)) of the polymer. The electrospun fibers could be induced to crimp by adjusting the operating temperature to be greater than that of the polymer glass-transition temperature. Moreover, the crimped fibers exhibited a toe region in their stress-strain profile that is characteristic of collagen present in tendons and ligaments. The crimp pattern was retained during in vitro degradation over 4 weeks. Primary bovine fibroblasts seeded onto these crimped fibers attached, proliferated, and deposited extracellular matrix (ECM) molecules on the surface of the fiber mats. These self-crimping fibers hold great promise for use in tissue engineering scaffolds for connective tissues that require fibers similar in structure to that of crimped collagen fibrils.

U2 - 10.1021/bm101078c

DO - 10.1021/bm101078c

M3 - Article

VL - 11

SP - 3624

EP - 3629

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 12

ER -

Surrao DC, Hayami JWS, Waldman SD, Amsden BG. Self-crimping, biodegradable, electrospun polymer microfibers. Biomacromolecules. 2010 Dec 13;11(12):3624-9. https://doi.org/10.1021/bm101078c