Selective monoesterification of malonic acid catalyzed by boric acid

Stephan M. Levonis, Laurent F. Bornaghi, Todd A. Houston*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Boric acid catalyzes the monoesterification of malonic acid, likely through a chelation mechanism that is not available to the monoester product. Under more forcing conditions, diesters form to some extent, but conditions can be optimized to favour the monoester product (56?80%). With the easily handled solid acid catalyst, these reactions can be run with excess alcohol as solvent or with stoichiometric amounts of alcohol in acetonitrile with moderate heating.

Original languageEnglish
Pages (from-to)821-823
Number of pages3
JournalAustralian Journal of Chemistry
Volume60
Issue number11
DOIs
Publication statusPublished - 2007
Externally publishedYes

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