Sanguinaria canadensis: Traditional medicine, phytochemical composition, biological activities and current uses

Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei Liu

Research output: Contribution to journalReview articleResearchpeer-review

16 Citations (Scopus)
67 Downloads (Pure)

Abstract

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

Original languageEnglish
Article number1414
JournalInternational Journal of Molecular Sciences
Volume17
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

Fingerprint

Sanguinaria
Alkaloids
alkaloids
Phytochemicals
Traditional Medicine
activity (biology)
Bioactivity
medicine
Medicine
Chemical analysis
toxicity
Toxicity
Benzophenanthridines
Mouthwashes
necrosis
Leukoplakia
Ointments
Rhizome
North American Indians
Drug products

Cite this

Croaker, Andrew ; King, Graham J. ; Pyne, John H. ; Anoopkumar-Dukie, Shailendra ; Liu, Lei. / Sanguinaria canadensis : Traditional medicine, phytochemical composition, biological activities and current uses. In: International Journal of Molecular Sciences. 2016 ; Vol. 17, No. 9.
@article{1ba98df0c0bf45479eb28826042056c7,
title = "Sanguinaria canadensis: Traditional medicine, phytochemical composition, biological activities and current uses",
abstract = "Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.",
author = "Andrew Croaker and King, {Graham J.} and Pyne, {John H.} and Shailendra Anoopkumar-Dukie and Lei Liu",
year = "2016",
month = "9",
day = "1",
doi = "10.3390/ijms17091414",
language = "English",
volume = "17",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

Sanguinaria canadensis : Traditional medicine, phytochemical composition, biological activities and current uses. / Croaker, Andrew; King, Graham J.; Pyne, John H.; Anoopkumar-Dukie, Shailendra; Liu, Lei.

In: International Journal of Molecular Sciences, Vol. 17, No. 9, 1414, 01.09.2016.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Sanguinaria canadensis

T2 - Traditional medicine, phytochemical composition, biological activities and current uses

AU - Croaker, Andrew

AU - King, Graham J.

AU - Pyne, John H.

AU - Anoopkumar-Dukie, Shailendra

AU - Liu, Lei

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

AB - Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=84984846134&partnerID=8YFLogxK

U2 - 10.3390/ijms17091414

DO - 10.3390/ijms17091414

M3 - Review article

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 9

M1 - 1414

ER -