Review article: Sepsis in the emergency department – Part 2: Investigations and monitoring

Amith Shetty*, Stephen P.J. Macdonald, Gerben Keijzers, Julian M. Williams, Benjamin Tang, Bas de Groot, Kelly Thompson, John F. Fraser, Simon Finfer, Rinaldo Bellomo, Jonathan Iredell

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

21 Citations (Scopus)


Sepsis is characterised by organ dysfunction resulting from infection, with no reliable single objective test and current diagnosis based on clinical features and results of investigations. In the ED, investigations may be conducted to diagnose infection as the cause of the presenting illness, identify the source, distinguish sepsis from uncomplicated infection (i.e. without organ dysfunction) and/ or risk stratification. Appropriate sample collection for microbiological testing remains key for subsequent confirmation of diagnosis and rationalisation of antimicrobials. Routine laboratory investigations such as creatinine, bilirubin, platelet count and lactate are now critical elements in the diagnosis of sepsis and septic shock. With no biomarker sufficiently validated to rule out bacterial infection in the ED, there remains substantial interest in biomarkers representing various pathogenic pathways. New technologies for screening multiple genes and proteins are identifying unique network ‘signatures’ of clinical interest. Other future directions include rapid detection of bacterial DNA in blood, genes for antibiotic resistance and EMR-based computational biomarkers that collate multiple information sources. Reliable, cost-effective tests, validated in the ED to promptly and accurately identify sepsis, and to guide initial antibiotic choices, are important goals of current research efforts.

Original languageEnglish
Pages (from-to)4-12
Number of pages9
JournalEMA - Emergency Medicine Australasia
Issue number1
Publication statusPublished - 1 Feb 2018


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