Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance

Stijn Soenen, Edwin C.M. Mariman, Neeltje Vogels, Freek G. Bouwman, Marcel den Hoed, Louise Brown, Margriet S. Westerterp-Plantenga*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)


Background: Genetic variation in the perilipin (PLIN) gene may play a role in the etiology and treatment of obesity. Objective: To examine different polymorphisms in the PLIN gene in relation to body-weight regulation. Methods: 118 subjects followed a 6 wk VLCD, followed by 1 year weight maintenance. Body-weight (BW), body-composition, leptin concentration, and polymorphisms of the PLIN gene: PLIN1:rs2289487, PLIN4:rs894160, PLIN6:rs1052700, PLIN5:rs2304795 and PLIN7:rs 2304796 were determined. Results: BW loss during VLCD was 7.0 ± 3.1 kg (p < 0.05), and BW regain was 3.7 ± 1.4 kg (p < 0.05), including changes in body mass index (BMI), waist-circumference, body-composition and leptin concentrations (p < 0.05). Linkage disequilibria were observed between PLIN1 and PLIN4: D' > 0.9, r2 = 0.72; PLIN5 and PLIN7: D' > 0.9, r2 = 0.85. In men, body weight, BMI, waist circumference, body fat, leptin concentrations were significantly lower for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). In women weight loss and loss of fat mass were larger for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). For PLIN6 genotypes body weight and body fat were lower for homozygotes of the minor allele (T/T) in the men; in the women leptin concentrations were lower. The haplotype of PLIN5 and PLIN7 consisting of A/G and G/G of PLIN5 and A/A of PLIN7 showed a reduction in FM: 5.9 ± 0.6 kg vs 3.1 ± 0.4 kg, % body fat: 5.5 ± 0.6% vs 2.2 ± 0.2%, and leptin: 20.5 ± 10.8 ng/ml vs 12.9 ± 6.7 ng/ml over time in the women (p < 0.05). Conclusion: Since the haplotype of the minor alleles PLIN1-4, PLIN5-7 and PLIN6, was related to body-weight regulation at a lower level of body-weight in the men as well in the women we conclude that the PLIN1-4, 6, and 5-7 locus appears as a genetic influencer of obesity risk in humans.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalPhysiology and Behavior
Issue number4-5
Publication statusPublished - 23 Mar 2009
Externally publishedYes


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