Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training

Yorgi Mavros, Shelley Kay, Kylie A. Simpson, Michael K. Baker, Yi Wang, Ren R. Zhao, Jacinda Meiklejohn, Mike Climstein, Anthony J. O'Sullivan, Nathan de Vos, Bernhard T. Baune, Steven N. Blair, David Simar, Kieron Rooney, Nalin A. Singh, Maria A. Fiatarone Singh

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Abstract

Background: Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on systemic inflammation, and whether reductions in systemic inflammation were associated with changes in body composition. We hypothesized that reductions in systemic inflammation following 12 months of PRT in older adults with type 2 diabetes would be associated with reductions in adiposity and increases in skeletal muscle mass. Methods: Participants (n = 103) were randomized to receive either PRT or sham-exercise, 3 days a week for 12 months. C-reactive protein (CRP) was used to assess systemic inflammation. Skeletal muscle mass and total fat mass were determined using bioelectrical impedance. Results: Twelve months of PRT tended to reduce CRP compared to sham exercise (β = -0.25, p = 0.087). Using linear mixed-effects models, the hypothesized relationships between body composition adaptations and CRP changes were significantly stronger for skeletal muscle mass (p = 0.04) and tended to be stronger for total fat mass (p = 0.07) following PRT when compared to sham-exercise. Using univariate regression models, stratified by group allocation, reductions in CRP were associated with increases in skeletal muscle mass (p = 0.01) and reductions in total fat mass (p = 0.02) in the PRT group, but not in the sham-exercise group (p = 0.87 and p = 0.32, respectively). Conclusions: We have shown for the first time that reductions in systemic inflammation in older adults with type 2 diabetes following PRT were associated with increases in skeletal muscle mass. Furthermore, reductions in CRP were associated with reductions in adiposity, but only when associated with PRT. Lifestyle interventions aimed at reducing systemic inflammation in older adults with type 2 diabetes should therefore incorporate anabolic exercise such as PRT to optimize the anti-inflammatory benefits of favorable body composition adaptations.

Original languageEnglish
Pages (from-to)111-120
Number of pages10
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume5
Issue number2
DOIs
Publication statusPublished - 2014

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Resistance Training
Body Composition
C-Reactive Protein
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Skeletal Muscle
Inflammation
Adiposity
Fats
Electric Impedance
Life Style
Chronic Disease
Anti-Inflammatory Agents
Obesity

Cite this

Mavros, Yorgi ; Kay, Shelley ; Simpson, Kylie A. ; Baker, Michael K. ; Wang, Yi ; Zhao, Ren R. ; Meiklejohn, Jacinda ; Climstein, Mike ; O'Sullivan, Anthony J. ; de Vos, Nathan ; Baune, Bernhard T. ; Blair, Steven N. ; Simar, David ; Rooney, Kieron ; Singh, Nalin A. ; Fiatarone Singh, Maria A. / Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. In: Journal of Cachexia, Sarcopenia and Muscle. 2014 ; Vol. 5, No. 2. pp. 111-120.
@article{36a02ecc87d04383ba6e669d0aa169f4,
title = "Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training",
abstract = "Background: Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on systemic inflammation, and whether reductions in systemic inflammation were associated with changes in body composition. We hypothesized that reductions in systemic inflammation following 12 months of PRT in older adults with type 2 diabetes would be associated with reductions in adiposity and increases in skeletal muscle mass. Methods: Participants (n = 103) were randomized to receive either PRT or sham-exercise, 3 days a week for 12 months. C-reactive protein (CRP) was used to assess systemic inflammation. Skeletal muscle mass and total fat mass were determined using bioelectrical impedance. Results: Twelve months of PRT tended to reduce CRP compared to sham exercise (β = -0.25, p = 0.087). Using linear mixed-effects models, the hypothesized relationships between body composition adaptations and CRP changes were significantly stronger for skeletal muscle mass (p = 0.04) and tended to be stronger for total fat mass (p = 0.07) following PRT when compared to sham-exercise. Using univariate regression models, stratified by group allocation, reductions in CRP were associated with increases in skeletal muscle mass (p = 0.01) and reductions in total fat mass (p = 0.02) in the PRT group, but not in the sham-exercise group (p = 0.87 and p = 0.32, respectively). Conclusions: We have shown for the first time that reductions in systemic inflammation in older adults with type 2 diabetes following PRT were associated with increases in skeletal muscle mass. Furthermore, reductions in CRP were associated with reductions in adiposity, but only when associated with PRT. Lifestyle interventions aimed at reducing systemic inflammation in older adults with type 2 diabetes should therefore incorporate anabolic exercise such as PRT to optimize the anti-inflammatory benefits of favorable body composition adaptations.",
author = "Yorgi Mavros and Shelley Kay and Simpson, {Kylie A.} and Baker, {Michael K.} and Yi Wang and Zhao, {Ren R.} and Jacinda Meiklejohn and Mike Climstein and O'Sullivan, {Anthony J.} and {de Vos}, Nathan and Baune, {Bernhard T.} and Blair, {Steven N.} and David Simar and Kieron Rooney and Singh, {Nalin A.} and {Fiatarone Singh}, {Maria A.}",
year = "2014",
doi = "10.1007/s13539-014-0134-1",
language = "English",
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pages = "111--120",
journal = "Journal of Cachexia, Sarcopenia and Muscle",
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Mavros, Y, Kay, S, Simpson, KA, Baker, MK, Wang, Y, Zhao, RR, Meiklejohn, J, Climstein, M, O'Sullivan, AJ, de Vos, N, Baune, BT, Blair, SN, Simar, D, Rooney, K, Singh, NA & Fiatarone Singh, MA 2014, 'Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training' Journal of Cachexia, Sarcopenia and Muscle, vol. 5, no. 2, pp. 111-120. https://doi.org/10.1007/s13539-014-0134-1

Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. / Mavros, Yorgi; Kay, Shelley; Simpson, Kylie A.; Baker, Michael K.; Wang, Yi; Zhao, Ren R.; Meiklejohn, Jacinda; Climstein, Mike; O'Sullivan, Anthony J.; de Vos, Nathan; Baune, Bernhard T.; Blair, Steven N.; Simar, David; Rooney, Kieron; Singh, Nalin A.; Fiatarone Singh, Maria A.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 5, No. 2, 2014, p. 111-120.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training

AU - Mavros, Yorgi

AU - Kay, Shelley

AU - Simpson, Kylie A.

AU - Baker, Michael K.

AU - Wang, Yi

AU - Zhao, Ren R.

AU - Meiklejohn, Jacinda

AU - Climstein, Mike

AU - O'Sullivan, Anthony J.

AU - de Vos, Nathan

AU - Baune, Bernhard T.

AU - Blair, Steven N.

AU - Simar, David

AU - Rooney, Kieron

AU - Singh, Nalin A.

AU - Fiatarone Singh, Maria A.

PY - 2014

Y1 - 2014

N2 - Background: Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on systemic inflammation, and whether reductions in systemic inflammation were associated with changes in body composition. We hypothesized that reductions in systemic inflammation following 12 months of PRT in older adults with type 2 diabetes would be associated with reductions in adiposity and increases in skeletal muscle mass. Methods: Participants (n = 103) were randomized to receive either PRT or sham-exercise, 3 days a week for 12 months. C-reactive protein (CRP) was used to assess systemic inflammation. Skeletal muscle mass and total fat mass were determined using bioelectrical impedance. Results: Twelve months of PRT tended to reduce CRP compared to sham exercise (β = -0.25, p = 0.087). Using linear mixed-effects models, the hypothesized relationships between body composition adaptations and CRP changes were significantly stronger for skeletal muscle mass (p = 0.04) and tended to be stronger for total fat mass (p = 0.07) following PRT when compared to sham-exercise. Using univariate regression models, stratified by group allocation, reductions in CRP were associated with increases in skeletal muscle mass (p = 0.01) and reductions in total fat mass (p = 0.02) in the PRT group, but not in the sham-exercise group (p = 0.87 and p = 0.32, respectively). Conclusions: We have shown for the first time that reductions in systemic inflammation in older adults with type 2 diabetes following PRT were associated with increases in skeletal muscle mass. Furthermore, reductions in CRP were associated with reductions in adiposity, but only when associated with PRT. Lifestyle interventions aimed at reducing systemic inflammation in older adults with type 2 diabetes should therefore incorporate anabolic exercise such as PRT to optimize the anti-inflammatory benefits of favorable body composition adaptations.

AB - Background: Reductions in skeletal muscle mass and increased adiposity are key elements in the aging process and in the pathophysiology of several chronic diseases. Systemic low grade inflammation associated with obesity has been shown to accelerate the age-related decline in skeletal muscle. The aim of this investigation was to determine the effects of 12 months of progressive resistance training (PRT) on systemic inflammation, and whether reductions in systemic inflammation were associated with changes in body composition. We hypothesized that reductions in systemic inflammation following 12 months of PRT in older adults with type 2 diabetes would be associated with reductions in adiposity and increases in skeletal muscle mass. Methods: Participants (n = 103) were randomized to receive either PRT or sham-exercise, 3 days a week for 12 months. C-reactive protein (CRP) was used to assess systemic inflammation. Skeletal muscle mass and total fat mass were determined using bioelectrical impedance. Results: Twelve months of PRT tended to reduce CRP compared to sham exercise (β = -0.25, p = 0.087). Using linear mixed-effects models, the hypothesized relationships between body composition adaptations and CRP changes were significantly stronger for skeletal muscle mass (p = 0.04) and tended to be stronger for total fat mass (p = 0.07) following PRT when compared to sham-exercise. Using univariate regression models, stratified by group allocation, reductions in CRP were associated with increases in skeletal muscle mass (p = 0.01) and reductions in total fat mass (p = 0.02) in the PRT group, but not in the sham-exercise group (p = 0.87 and p = 0.32, respectively). Conclusions: We have shown for the first time that reductions in systemic inflammation in older adults with type 2 diabetes following PRT were associated with increases in skeletal muscle mass. Furthermore, reductions in CRP were associated with reductions in adiposity, but only when associated with PRT. Lifestyle interventions aimed at reducing systemic inflammation in older adults with type 2 diabetes should therefore incorporate anabolic exercise such as PRT to optimize the anti-inflammatory benefits of favorable body composition adaptations.

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U2 - 10.1007/s13539-014-0134-1

DO - 10.1007/s13539-014-0134-1

M3 - Article

VL - 5

SP - 111

EP - 120

JO - Journal of Cachexia, Sarcopenia and Muscle

JF - Journal of Cachexia, Sarcopenia and Muscle

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