Redefining functional models of basal ganglia organization: Role for the posteroventral pallidum in linguistic processing?

Brooke Mai Whelan, Bruce E. Murdoch, Deborah G. Theodoros, Ross Darnell, Peter A. Silburn, Bruce Hall

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric between-groups comparisons were conducted and reliable change indices calculated, relative to baseline/3-month follow-up difference scores. Group-wise statistical comparisons between the three groups failed to reveal significant postoperative changes in language performance. Case-by-case data analysis relative to clinically consequential change indices revealed reliable alterations in performance across several language variables as a consequence of BPVP. These findings lend support to models of subcortical participation in language, which promote a role for the GPi in lexical-semantic manipulation mechanisms. Concomitant improvements and decrements in postoperative performance were interpreted within the context of additive and subtractive postlesional effects. Relative to parkinsonian cohorts, clinically reliable versus statistically significant changes on a case by case basis may provide the most accurate method of characterizing the way in which pathophysiologically divergent basal ganglia linguistic circuits respond to BPVP.

Original languageEnglish
Pages (from-to)1267-1278
Number of pages12
JournalMovement Disorders
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Fingerprint

Pallidotomy
Globus Pallidus
Linguistics
Basal Ganglia
Language
Aptitude
Semantics
Parkinson Disease
Cognition

Cite this

Whelan, B. M., Murdoch, B. E., Theodoros, D. G., Darnell, R., Silburn, P. A., & Hall, B. (2004). Redefining functional models of basal ganglia organization: Role for the posteroventral pallidum in linguistic processing? Movement Disorders, 19(11), 1267-1278. https://doi.org/10.1002/mds.20252
Whelan, Brooke Mai ; Murdoch, Bruce E. ; Theodoros, Deborah G. ; Darnell, Ross ; Silburn, Peter A. ; Hall, Bruce. / Redefining functional models of basal ganglia organization : Role for the posteroventral pallidum in linguistic processing?. In: Movement Disorders. 2004 ; Vol. 19, No. 11. pp. 1267-1278.
@article{81744e761b474d77b33db16e5335730f,
title = "Redefining functional models of basal ganglia organization: Role for the posteroventral pallidum in linguistic processing?",
abstract = "Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric between-groups comparisons were conducted and reliable change indices calculated, relative to baseline/3-month follow-up difference scores. Group-wise statistical comparisons between the three groups failed to reveal significant postoperative changes in language performance. Case-by-case data analysis relative to clinically consequential change indices revealed reliable alterations in performance across several language variables as a consequence of BPVP. These findings lend support to models of subcortical participation in language, which promote a role for the GPi in lexical-semantic manipulation mechanisms. Concomitant improvements and decrements in postoperative performance were interpreted within the context of additive and subtractive postlesional effects. Relative to parkinsonian cohorts, clinically reliable versus statistically significant changes on a case by case basis may provide the most accurate method of characterizing the way in which pathophysiologically divergent basal ganglia linguistic circuits respond to BPVP.",
author = "Whelan, {Brooke Mai} and Murdoch, {Bruce E.} and Theodoros, {Deborah G.} and Ross Darnell and Silburn, {Peter A.} and Bruce Hall",
year = "2004",
month = "11",
doi = "10.1002/mds.20252",
language = "English",
volume = "19",
pages = "1267--1278",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley & Sons",
number = "11",

}

Whelan, BM, Murdoch, BE, Theodoros, DG, Darnell, R, Silburn, PA & Hall, B 2004, 'Redefining functional models of basal ganglia organization: Role for the posteroventral pallidum in linguistic processing?' Movement Disorders, vol. 19, no. 11, pp. 1267-1278. https://doi.org/10.1002/mds.20252

Redefining functional models of basal ganglia organization : Role for the posteroventral pallidum in linguistic processing? / Whelan, Brooke Mai; Murdoch, Bruce E.; Theodoros, Deborah G.; Darnell, Ross; Silburn, Peter A.; Hall, Bruce.

In: Movement Disorders, Vol. 19, No. 11, 11.2004, p. 1267-1278.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Redefining functional models of basal ganglia organization

T2 - Role for the posteroventral pallidum in linguistic processing?

AU - Whelan, Brooke Mai

AU - Murdoch, Bruce E.

AU - Theodoros, Deborah G.

AU - Darnell, Ross

AU - Silburn, Peter A.

AU - Hall, Bruce

PY - 2004/11

Y1 - 2004/11

N2 - Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric between-groups comparisons were conducted and reliable change indices calculated, relative to baseline/3-month follow-up difference scores. Group-wise statistical comparisons between the three groups failed to reveal significant postoperative changes in language performance. Case-by-case data analysis relative to clinically consequential change indices revealed reliable alterations in performance across several language variables as a consequence of BPVP. These findings lend support to models of subcortical participation in language, which promote a role for the GPi in lexical-semantic manipulation mechanisms. Concomitant improvements and decrements in postoperative performance were interpreted within the context of additive and subtractive postlesional effects. Relative to parkinsonian cohorts, clinically reliable versus statistically significant changes on a case by case basis may provide the most accurate method of characterizing the way in which pathophysiologically divergent basal ganglia linguistic circuits respond to BPVP.

AB - Traditionally the basal ganglia have been implicated in motor behavior, as they are involved in both the execution of automatic actions and the modification of ongoing actions in novel contexts. Corresponding to cognition, the role of the basal ganglia has not been defined as explicitly. Relative to linguistic processes, contemporary theories of subcortical participation in language have endorsed a role for the globus pallidus internus (GPi) in the control of lexical-semantic operations. However, attempts to empirically validate these postulates have been largely limited to neuropsychological investigations of verbal fluency abilities subsequent to pallidotomy. We evaluated the impact of bilateral posteroventral pallidotomy (BPVP) on language function across a range of general and high-level linguistic abilities, and validated/extended working theories of pallidal participation in language. Comprehensive linguistic profiles were compiled up to 1 month before and 3 months after BPVP in 6 subjects with Parkinson's disease (PD). Commensurate linguistic profiles were also gathered over a 3-month period for a nonsurgical control cohort of 16 subjects with PD and a group of 16 non-neurologically impaired controls (NC). Nonparametric between-groups comparisons were conducted and reliable change indices calculated, relative to baseline/3-month follow-up difference scores. Group-wise statistical comparisons between the three groups failed to reveal significant postoperative changes in language performance. Case-by-case data analysis relative to clinically consequential change indices revealed reliable alterations in performance across several language variables as a consequence of BPVP. These findings lend support to models of subcortical participation in language, which promote a role for the GPi in lexical-semantic manipulation mechanisms. Concomitant improvements and decrements in postoperative performance were interpreted within the context of additive and subtractive postlesional effects. Relative to parkinsonian cohorts, clinically reliable versus statistically significant changes on a case by case basis may provide the most accurate method of characterizing the way in which pathophysiologically divergent basal ganglia linguistic circuits respond to BPVP.

UR - http://www.scopus.com/inward/record.url?scp=8844273395&partnerID=8YFLogxK

U2 - 10.1002/mds.20252

DO - 10.1002/mds.20252

M3 - Article

VL - 19

SP - 1267

EP - 1278

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 11

ER -