Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: An analysis of the supporting evidence

Bradley Baker*, Azmat Ali, Liz Isenring

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

3 Citations (Scopus)

Abstract

Introduction: Manganese (Mn) toxicity is often observed in adult patients receiving long-term home parenteral nutrition (HPN), and differing recommendations on the safe level of Mn administration to these patients have been made in the literature over the past 10 years. Methods: This systematic review used the National Health and Medical Research Council (NHMRC) evidence hierarchy to assess the design and strength of individual studies (high I to low IV) and the overall grade of evidence (grade A high to grade D low). Results: Eight studies met the inclusion criteria. Levels of evidence ranged from high (NHMRC II) to mid-level (III-3). A widespread recommendation in the literature for patients receiving long-term HPN is 55 μg (1 μmol) Mn/d. Conclusion: The recommendation of 55 μg (1μmol) Mn/d is of moderate-strength evidence (NHMRC B grade). There is limited evidence to support not supplementing Mn to patients receiving long-term HPN. Further intervention studies providing high-level evidence (II and above) are required to determine the safety of not supplementing Mn to all patients receiving long-term HPN.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalNutrition in Clinical Practice
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016

Fingerprint Dive into the research topics of 'Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: An analysis of the supporting evidence'. Together they form a unique fingerprint.

  • Related Projects

    Bond University Nutrition and Dietetics Research Group Research Collaborations with External Clinical Partners

    Marshall, S., Isenring, E., MacKenzie-Shalders, K., Kelly, J., Campbell, K., Van der Meij, B., Cox, G., Reidlinger, D., Mayr, H., Banbury, M., Nucera, R., Jenkins, J., McCray, S., Canavan, R., Parker, B., de Groot, L., Cohen, F., Rich, G., Soni, A., McCarthy, A. L., Mackay, H., Young, A. M., Hickman, I., Wilkinson, S. A., Kiss, N. & Ali, A.

    1/01/14 → …

    Project: Research

    Cite this