Recent developments in PARP14 research

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7 Citations (Scopus)


This review aims to reflect upon the major developments in PARP14 research from late 2017 to early 2020. In doing so, this report will focus on the continual elucidation of PARP14's function including an emerging role in viral replication. This is in addition to other functional developments in cancer and inflammation, along with reflecting upon the leads in inhibitor design, including the increased attention toward the macrodomain. This report will also include a brief recap on contemporary poly(ADP-ribose) polymerase inhibitors and reflect upon the development surrounding the other poly(ADP-ribose) polymerases to overall give a succinct update to assist the development of selective PARP14 inhibitors.

Original languageEnglish
Pages (from-to)1657-1667
Number of pages11
JournalFuture Medicinal Chemistry
Issue number18
Early online date7 Sept 2020
Publication statusPublished - Sept 2020


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