Rapidly mutating Y-STRs multiplex genotyping panel to investigate UAE population

R. Alghafri; W. Goodwin; S. Hadi

doi:10.1016/j.fsigss.2013.10.103

Rapidly mutating Y-STRs multiplex genotyping panel to investigate UAE population

R. Alghafri, W. Goodwin, S. Hadi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Development of a new multiplex comprising of 13 Rapidly Mutating Y STRs (RM Y-STR) is presented. The multiplex will aid investigating the human genetic structure of United Arab Emirates (UAE) populations and would also be used to investigate unresolved forensic cases in Dubai Forensic Laboratory. Thirteen markers have been included in the multiplex. A mini validation of the new multiplex has been carried out including specificity, sensitivity and mixture studies. These markers have been analysed in 600 male samples from UAE population. Allelic frequencies, haplotype diversity and discrimination capacity were determined for the 13 RM Y-STRs. Mutations pattern analysis of the RM Y-STR loci in a typical UAE family has also been carried out.

Original language	English
Journal	Forensic Science International: Genetics Supplement Series
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.fsigss.2013.10.103
Publication status	Published - 30 Oct 2013
Externally published	Yes

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10.1016/j.fsigss.2013.10.103

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AB - Development of a new multiplex comprising of 13 Rapidly Mutating Y STRs (RM Y-STR) is presented. The multiplex will aid investigating the human genetic structure of United Arab Emirates (UAE) populations and would also be used to investigate unresolved forensic cases in Dubai Forensic Laboratory. Thirteen markers have been included in the multiplex. A mini validation of the new multiplex has been carried out including specificity, sensitivity and mixture studies. These markers have been analysed in 600 male samples from UAE population. Allelic frequencies, haplotype diversity and discrimination capacity were determined for the 13 RM Y-STRs. Mutations pattern analysis of the RM Y-STR loci in a typical UAE family has also been carried out.

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Rapidly mutating Y-STRs multiplex genotyping panel to investigate UAE population

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