Random measurements of adiponectin and IL-6 may not be indicative of the 24-h profile in critically ill patients

Katherine Robinson*, Mark Jones, Jenny Ordonez, Jeffrey Grice, Ben Davidson, John Prins, Bala Venkatesh

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Context The anti-inflammatory role of adiponectin has prompted interest in a potential role in acute inflammatory conditions associated with critical illness. It is unclear whether a random adiponectin measurement adequately reflects the 24-h profile in critically ill patients. Objective To assess the temporal profile of total and high molecular weight (HMW) adiponectin and interleukin-6 (IL-6) in 15 critically ill patients. Design A prospective, observational study. Setting Level II intensive care unit in a metropolitan hospital. Patients or Other Participants Fifteen critically ill patients expected to stay in the ICU for longer than 48 h were eligible for enrolment. Intervention(s) None. Main Outcome Measure(s) Serial, hourly measurements of total and HMW adiponectin and IL-6. Results Over a 24-h period, total and HMW adiponectin display considerable within-patient variability (coefficient of variation 34% and 87% respectively) and show no trend over time. Averaging 2 or 3 continuous measures reduced within-patient variability of both total and HMW adiponectin by up to 50% compared to one measure. There was a negative correlation between serum glucose and adiponectin (total P = 0·016, HMW P = 0·039). No relationship existed between adiponectin and IL-6 (total P = 0·62, HMW P = 0·35). Conclusions Marked within-patient, hourly variability in total and HMW adiponectin is evident in critically ill patients. A random measurement may not be reflective of the 24-h profile in these patients. A negative correlation exists between adiponectin and blood glucose levels and a positive correlation between adiponectin and oxygen saturation. No clear relationship exists between adiponectin and IL-6.

Original languageEnglish
Pages (from-to)892-898
Number of pages7
JournalClinical Endocrinology
Issue number6
Publication statusPublished - Dec 2013
Externally publishedYes


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