Quantitative variation in H-2-antigen expression: Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Further evidence for quantitative variation in H-2-antigen expression in F1 hybrids is described. Spleen cells from nine different F1 hybrids were compared with parental strain cells for differences in H-2K- and H-2D-antigen expression by quantitative absorption analysis and in an125I-radioimmunoassay using anti-H-2 sera. Some K and D antigens are expressed in two to three times smaller amounts in F1 hybrids, while others are approximately equally expressed. There was no evidence for eitherI-region control or parental influence in the genetic control of H-2-antigen expression. Expression of K and D antigens in an F1 hybrid (compared with parental cells) is dependent on theK andD allelic composition of the hybrid, in that some alleles tend to dominate over others. In four different F1 hybrids,K k was more strongly expressed thanK b , while, in other F1 hybrids,K d predominated over bothK k andK b . Similarly,D b dominated overD d in five different F1 hybrids, while no obvious dominance pattern was found in F1 hybrids carryingD k .
Original languageEnglish
Pages (from-to)241-254
Number of pages14
JournalImmunogenetics
Volume11
Issue number1
DOIs
Publication statusPublished - 1980
Externally publishedYes

Fingerprint

H-2 Antigens
Radioimmunoassay
Spleen
Alleles

Cite this

@article{fa7f14d04b004be4882113f1891f5fb3,
title = "Quantitative variation in H-2-antigen expression: Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice",
abstract = "Further evidence for quantitative variation in H-2-antigen expression in F1 hybrids is described. Spleen cells from nine different F1 hybrids were compared with parental strain cells for differences in H-2K- and H-2D-antigen expression by quantitative absorption analysis and in an125I-radioimmunoassay using anti-H-2 sera. Some K and D antigens are expressed in two to three times smaller amounts in F1 hybrids, while others are approximately equally expressed. There was no evidence for eitherI-region control or parental influence in the genetic control of H-2-antigen expression. Expression of K and D antigens in an F1 hybrid (compared with parental cells) is dependent on theK andD allelic composition of the hybrid, in that some alleles tend to dominate over others. In four different F1 hybrids,K k was more strongly expressed thanK b , while, in other F1 hybrids,K d predominated over bothK k andK b . Similarly,D b dominated overD d in five different F1 hybrids, while no obvious dominance pattern was found in F1 hybrids carryingD k .",
author = "O'Neill, {Helen C}",
year = "1980",
doi = "10.1007/BF01567791",
language = "English",
volume = "11",
pages = "241--254",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer",
number = "1",

}

Quantitative variation in H-2-antigen expression : Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice. / O'Neill, Helen C.

In: Immunogenetics, Vol. 11, No. 1, 1980, p. 241-254.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Quantitative variation in H-2-antigen expression

T2 - Evidence for a dominance pattern in H-2K and H-2D expression in F1 hybrid mice

AU - O'Neill, Helen C

PY - 1980

Y1 - 1980

N2 - Further evidence for quantitative variation in H-2-antigen expression in F1 hybrids is described. Spleen cells from nine different F1 hybrids were compared with parental strain cells for differences in H-2K- and H-2D-antigen expression by quantitative absorption analysis and in an125I-radioimmunoassay using anti-H-2 sera. Some K and D antigens are expressed in two to three times smaller amounts in F1 hybrids, while others are approximately equally expressed. There was no evidence for eitherI-region control or parental influence in the genetic control of H-2-antigen expression. Expression of K and D antigens in an F1 hybrid (compared with parental cells) is dependent on theK andD allelic composition of the hybrid, in that some alleles tend to dominate over others. In four different F1 hybrids,K k was more strongly expressed thanK b , while, in other F1 hybrids,K d predominated over bothK k andK b . Similarly,D b dominated overD d in five different F1 hybrids, while no obvious dominance pattern was found in F1 hybrids carryingD k .

AB - Further evidence for quantitative variation in H-2-antigen expression in F1 hybrids is described. Spleen cells from nine different F1 hybrids were compared with parental strain cells for differences in H-2K- and H-2D-antigen expression by quantitative absorption analysis and in an125I-radioimmunoassay using anti-H-2 sera. Some K and D antigens are expressed in two to three times smaller amounts in F1 hybrids, while others are approximately equally expressed. There was no evidence for eitherI-region control or parental influence in the genetic control of H-2-antigen expression. Expression of K and D antigens in an F1 hybrid (compared with parental cells) is dependent on theK andD allelic composition of the hybrid, in that some alleles tend to dominate over others. In four different F1 hybrids,K k was more strongly expressed thanK b , while, in other F1 hybrids,K d predominated over bothK k andK b . Similarly,D b dominated overD d in five different F1 hybrids, while no obvious dominance pattern was found in F1 hybrids carryingD k .

U2 - 10.1007/BF01567791

DO - 10.1007/BF01567791

M3 - Article

VL - 11

SP - 241

EP - 254

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 1

ER -