Prothymocyte seeding in the thymus

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Abstract

A major gap in our understanding of T lymphocyte development is the process of stem cell differentiation into T lymphocyte precursors. An important question is whether bone marrow-derived stem cells become committed to T lymphoid lineage within the bone marrow, or whether this occurs once cells have entered the microenvironment of the thymus. Attempts to identify a haemapoietic precursor of thymocytes in mice, a "prothymocyte", have involved cell transfer experiments involving isolated and selected populations of bone marrow stem cells, as well as transformed or continuous cell lines representing early stage in mouse T cell development. Current information on the properties of stem cells which can seed the thymus is reviewed in this paper, and the possibility that progenitor T cells may be identified by their expression of receptor(s) which localise them into the thymus is considered.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalImmunology Letters
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1991
Externally publishedYes

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Thymus Gland
Stem Cells
T-Lymphocytes
Bone Marrow
Thymocytes
Bone Marrow Cells
Cell Differentiation
Seeds
Cell Line
Population

Cite this

O'Neill, H C. / Prothymocyte seeding in the thymus. In: Immunology Letters. 1991 ; Vol. 27, No. 1. pp. 1-6.
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Prothymocyte seeding in the thymus. / O'Neill, H C.

In: Immunology Letters, Vol. 27, No. 1, 01.1991, p. 1-6.

Research output: Contribution to journalReview articleResearchpeer-review

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