Proteins and satiety: Implications for weight management

Stijn Soenen, Margriet S. Westerterp-Plantenga*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)


Purpose of review
To highlight the satiating background and effects of proteins and their implications for weight management.Recent findings The satiating effect of protein is the key player in body-weight loss and body-weight maintenance thereafter. Specific high-protein meals or high-protein diets induced satiety require a realistic bandwidth of energy intake, protein concentrations, texture, and timing of assessment of effects. Satiety is nutrient specifically supported by elevated amino acid concentrations, responses of anorexigenic hormones or protein-induced energy expenditure. During long-term high-protein diets sustained satiety, energy expenditure, and sparing fat-free body mass are essential. For effects due to satiety, ad libitum energy intake conditions are necessary. Adverse events related to kidney damage may occur with sulphur-containing amino acids; individuals with obesity, metabolic syndrome and diabetes mellitus II may be susceptible groups.Summary Highly controlled medium-term studies overcoming possible differences due to texture, timing and macronutrient exchange, and assessing satiety, energy expenditure and substrate oxidation at the same time, need to be executed with a realistic bandwidth of different types of proteins in overweight individuals in different energy balances.
Original languageEnglish
Pages (from-to)747-751
Number of pages5
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number6
Publication statusPublished - 1 Nov 2008
Externally publishedYes


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