Protein anabolic resistance in cancer: Does it really exist?

Mariëlle P K J Engelen, Barbara S van der Meij, Nicolaas E P Deutz

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional intervention, but does recent evidence actually support this? We will discuss recent literature that casts doubt on attenuated anabolic potential in cancer.

RECENT FINDINGS: Although anabolic resistance was observed in the past, more recent studies have shown that advanced cancer patients have an anabolic potential after intake of high-quality proteins. Furthermore, a consistent linear relationship is observed in cancer between (essential) amino acid availability from the diet and net protein gain. The studied cancer patients, however, were often characterized by a normal or obese body weight, following the trend in the general population, and mild systemic inflammation. Factors like recent chemotherapy, surgery, or cachexia do not seem to attenuate the anabolic potential to feeding.

SUMMARY: Cancer patients have a normal anabolic potential which relates to the amount of essential amino acids in the meal. It remains to be determined if this is also the case in weak cancer patients with a short life expectancy and high systemic inflammation.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2016
Externally publishedYes

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Neoplasms
Proteins
Essential Amino Acids
Inflammation
Cachexia
Life Expectancy
Meals
Weight Loss
Body Weight
Diet
Drug Therapy
Muscles
Survival
Population
Therapeutics

Cite this

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title = "Protein anabolic resistance in cancer: Does it really exist?",
abstract = "PURPOSE OF REVIEW: Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional intervention, but does recent evidence actually support this? We will discuss recent literature that casts doubt on attenuated anabolic potential in cancer.RECENT FINDINGS: Although anabolic resistance was observed in the past, more recent studies have shown that advanced cancer patients have an anabolic potential after intake of high-quality proteins. Furthermore, a consistent linear relationship is observed in cancer between (essential) amino acid availability from the diet and net protein gain. The studied cancer patients, however, were often characterized by a normal or obese body weight, following the trend in the general population, and mild systemic inflammation. Factors like recent chemotherapy, surgery, or cachexia do not seem to attenuate the anabolic potential to feeding.SUMMARY: Cancer patients have a normal anabolic potential which relates to the amount of essential amino acids in the meal. It remains to be determined if this is also the case in weak cancer patients with a short life expectancy and high systemic inflammation.",
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Protein anabolic resistance in cancer: Does it really exist? / Engelen, Mariëlle P K J; van der Meij, Barbara S; Deutz, Nicolaas E P.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 19, No. 1, 01.2016, p. 39-47.

Research output: Contribution to journalArticleResearchpeer-review

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AU - van der Meij, Barbara S

AU - Deutz, Nicolaas E P

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AB - PURPOSE OF REVIEW: Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional intervention, but does recent evidence actually support this? We will discuss recent literature that casts doubt on attenuated anabolic potential in cancer.RECENT FINDINGS: Although anabolic resistance was observed in the past, more recent studies have shown that advanced cancer patients have an anabolic potential after intake of high-quality proteins. Furthermore, a consistent linear relationship is observed in cancer between (essential) amino acid availability from the diet and net protein gain. The studied cancer patients, however, were often characterized by a normal or obese body weight, following the trend in the general population, and mild systemic inflammation. Factors like recent chemotherapy, surgery, or cachexia do not seem to attenuate the anabolic potential to feeding.SUMMARY: Cancer patients have a normal anabolic potential which relates to the amount of essential amino acids in the meal. It remains to be determined if this is also the case in weak cancer patients with a short life expectancy and high systemic inflammation.

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