Protection against Radiotherapy-Induced Toxicity

Susan Hall, Santosh Rudrawar, Matthew Zunk, Nijole Bernaitis, Devinder Arora, Catherine M McDermott, Shailendra Anoopkumar-Dukie

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

Original languageEnglish
Article number22
Number of pages18
JournalAntioxidants (Basel, Switzerland)
Volume5
Issue number3
DOIs
Publication statusPublished - 1 Sep 2016

Fingerprint

Radiotherapy
Toxicity
Radiation
Therapeutics
Neoplasms

Cite this

Hall, S., Rudrawar, S., Zunk, M., Bernaitis, N., Arora, D., McDermott, C. M., & Anoopkumar-Dukie, S. (2016). Protection against Radiotherapy-Induced Toxicity. Antioxidants (Basel, Switzerland), 5(3), [22]. https://doi.org/10.3390/antiox5030022
Hall, Susan ; Rudrawar, Santosh ; Zunk, Matthew ; Bernaitis, Nijole ; Arora, Devinder ; McDermott, Catherine M ; Anoopkumar-Dukie, Shailendra. / Protection against Radiotherapy-Induced Toxicity. In: Antioxidants (Basel, Switzerland). 2016 ; Vol. 5, No. 3.
@article{39254b3d07244e2fa29376e03063c72e,
title = "Protection against Radiotherapy-Induced Toxicity",
abstract = "Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60{\%} of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.",
author = "Susan Hall and Santosh Rudrawar and Matthew Zunk and Nijole Bernaitis and Devinder Arora and McDermott, {Catherine M} and Shailendra Anoopkumar-Dukie",
year = "2016",
month = "9",
day = "1",
doi = "10.3390/antiox5030022",
language = "English",
volume = "5",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "MDPI",
number = "3",

}

Hall, S, Rudrawar, S, Zunk, M, Bernaitis, N, Arora, D, McDermott, CM & Anoopkumar-Dukie, S 2016, 'Protection against Radiotherapy-Induced Toxicity' Antioxidants (Basel, Switzerland), vol. 5, no. 3, 22. https://doi.org/10.3390/antiox5030022

Protection against Radiotherapy-Induced Toxicity. / Hall, Susan; Rudrawar, Santosh; Zunk, Matthew; Bernaitis, Nijole; Arora, Devinder; McDermott, Catherine M; Anoopkumar-Dukie, Shailendra.

In: Antioxidants (Basel, Switzerland), Vol. 5, No. 3, 22, 01.09.2016.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Protection against Radiotherapy-Induced Toxicity

AU - Hall, Susan

AU - Rudrawar, Santosh

AU - Zunk, Matthew

AU - Bernaitis, Nijole

AU - Arora, Devinder

AU - McDermott, Catherine M

AU - Anoopkumar-Dukie, Shailendra

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

AB - Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

UR - http://www.scopus.com/inward/record.url?scp=85010288611&partnerID=8YFLogxK

U2 - 10.3390/antiox5030022

DO - 10.3390/antiox5030022

M3 - Article

VL - 5

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 3

M1 - 22

ER -