Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders

Catherine Clumeck, Sarah Suarez Garcia, Mathieu Bourguignon, Vincent Wens, Marc Op De Beeck, Brice Marty, Nicolas Deconinck, Marie Vincianne Soncarrieu, Serge Goldman, Veikko Jousmäki, Patrick Van Bogaert, Xavier De Tiège

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Purpose: Investigating the steadiness of the phase-coupling between the time-course of the reader's voice and brain signals of subjects with autism spectrum disorder (ASD) passively listening to connected speech using magnetoencephalography (MEG). In typically developed subjects, such coupling occurs at the right posterior temporal sulcus (pSTS) for frequencies below 1 Hz, and reflects the neural processing of sentence-level rhythmic prosody at the prelexical level. Methods: Cortical neuromagnetic signals were recorded with MEG (Elekta Oy, Finland) while seven right-handed and native French-speaking ASD subjects (six males, one female, range: 13-20 years) listened to live (Live) or recorded (Recorded) voices continuously reading a text in French for five minutes. Coherence was computed between the reader's voice time-course and ASD subjects' MEG signals. Coherent neural sources were subsequently reconstructed using a beamformer. Key findings: Significant coupling was found at 0.5 Hz in all ASD subjects in Live and in six subjects in Recorded. Coherent sources were located close to the right pSTS in both conditions. No significant difference was found in coherence levels between Live and Recorded , and between ASD subjects and ten typically developed subjects (right-handed, native French-speaking adults, 5 males, 5 females, age range: 21-38 years) included in a previous study. Significance: This study discloses a preserved coupling between the reader's voice and ASD subjects' cortical activity at the right pSTS. These findings support the existence of preserved neural processing of sentence-level rhythmic prosody in ASD. The preservation of early cortical processing of prosodic elements in verbal language might be exploited in therapeutic interventions in ASD.

Original languageEnglish
Article numbere92329
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - 24 Mar 2014
Externally publishedYes

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Magnetoencephalography
Temporal Lobe
Processing
Brain
Autism Spectrum Disorder
autism
Finland
Reading
Language
brain
therapeutics
magnetoencephalography

Cite this

Clumeck, C., Garcia, S. S., Bourguignon, M., Wens, V., Op De Beeck, M., Marty, B., ... De Tiège, X. (2014). Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders. PLoS One, 9(3), [e92329]. https://doi.org/10.1371/journal.pone.0092329
Clumeck, Catherine ; Garcia, Sarah Suarez ; Bourguignon, Mathieu ; Wens, Vincent ; Op De Beeck, Marc ; Marty, Brice ; Deconinck, Nicolas ; Soncarrieu, Marie Vincianne ; Goldman, Serge ; Jousmäki, Veikko ; Van Bogaert, Patrick ; De Tiège, Xavier. / Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders. In: PLoS One. 2014 ; Vol. 9, No. 3.
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abstract = "Purpose: Investigating the steadiness of the phase-coupling between the time-course of the reader's voice and brain signals of subjects with autism spectrum disorder (ASD) passively listening to connected speech using magnetoencephalography (MEG). In typically developed subjects, such coupling occurs at the right posterior temporal sulcus (pSTS) for frequencies below 1 Hz, and reflects the neural processing of sentence-level rhythmic prosody at the prelexical level. Methods: Cortical neuromagnetic signals were recorded with MEG (Elekta Oy, Finland) while seven right-handed and native French-speaking ASD subjects (six males, one female, range: 13-20 years) listened to live (Live) or recorded (Recorded) voices continuously reading a text in French for five minutes. Coherence was computed between the reader's voice time-course and ASD subjects' MEG signals. Coherent neural sources were subsequently reconstructed using a beamformer. Key findings: Significant coupling was found at 0.5 Hz in all ASD subjects in Live and in six subjects in Recorded. Coherent sources were located close to the right pSTS in both conditions. No significant difference was found in coherence levels between Live and Recorded , and between ASD subjects and ten typically developed subjects (right-handed, native French-speaking adults, 5 males, 5 females, age range: 21-38 years) included in a previous study. Significance: This study discloses a preserved coupling between the reader's voice and ASD subjects' cortical activity at the right pSTS. These findings support the existence of preserved neural processing of sentence-level rhythmic prosody in ASD. The preservation of early cortical processing of prosodic elements in verbal language might be exploited in therapeutic interventions in ASD.",
author = "Catherine Clumeck and Garcia, {Sarah Suarez} and Mathieu Bourguignon and Vincent Wens and {Op De Beeck}, Marc and Brice Marty and Nicolas Deconinck and Soncarrieu, {Marie Vincianne} and Serge Goldman and Veikko Jousm{\"a}ki and {Van Bogaert}, Patrick and {De Ti{\`e}ge}, Xavier",
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Clumeck, C, Garcia, SS, Bourguignon, M, Wens, V, Op De Beeck, M, Marty, B, Deconinck, N, Soncarrieu, MV, Goldman, S, Jousmäki, V, Van Bogaert, P & De Tiège, X 2014, 'Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders', PLoS One, vol. 9, no. 3, e92329. https://doi.org/10.1371/journal.pone.0092329

Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders. / Clumeck, Catherine; Garcia, Sarah Suarez; Bourguignon, Mathieu; Wens, Vincent; Op De Beeck, Marc; Marty, Brice; Deconinck, Nicolas; Soncarrieu, Marie Vincianne; Goldman, Serge; Jousmäki, Veikko; Van Bogaert, Patrick; De Tiège, Xavier.

In: PLoS One, Vol. 9, No. 3, e92329, 24.03.2014.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Preserved coupling between the reader's voice and the listener's cortical activity in autism spectrum disorders

AU - Clumeck, Catherine

AU - Garcia, Sarah Suarez

AU - Bourguignon, Mathieu

AU - Wens, Vincent

AU - Op De Beeck, Marc

AU - Marty, Brice

AU - Deconinck, Nicolas

AU - Soncarrieu, Marie Vincianne

AU - Goldman, Serge

AU - Jousmäki, Veikko

AU - Van Bogaert, Patrick

AU - De Tiège, Xavier

PY - 2014/3/24

Y1 - 2014/3/24

N2 - Purpose: Investigating the steadiness of the phase-coupling between the time-course of the reader's voice and brain signals of subjects with autism spectrum disorder (ASD) passively listening to connected speech using magnetoencephalography (MEG). In typically developed subjects, such coupling occurs at the right posterior temporal sulcus (pSTS) for frequencies below 1 Hz, and reflects the neural processing of sentence-level rhythmic prosody at the prelexical level. Methods: Cortical neuromagnetic signals were recorded with MEG (Elekta Oy, Finland) while seven right-handed and native French-speaking ASD subjects (six males, one female, range: 13-20 years) listened to live (Live) or recorded (Recorded) voices continuously reading a text in French for five minutes. Coherence was computed between the reader's voice time-course and ASD subjects' MEG signals. Coherent neural sources were subsequently reconstructed using a beamformer. Key findings: Significant coupling was found at 0.5 Hz in all ASD subjects in Live and in six subjects in Recorded. Coherent sources were located close to the right pSTS in both conditions. No significant difference was found in coherence levels between Live and Recorded , and between ASD subjects and ten typically developed subjects (right-handed, native French-speaking adults, 5 males, 5 females, age range: 21-38 years) included in a previous study. Significance: This study discloses a preserved coupling between the reader's voice and ASD subjects' cortical activity at the right pSTS. These findings support the existence of preserved neural processing of sentence-level rhythmic prosody in ASD. The preservation of early cortical processing of prosodic elements in verbal language might be exploited in therapeutic interventions in ASD.

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