Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis

Matthew John Burstow, Rossita Mohamad Yunus, Shahjahan Khan, Breda Memon, Muhammed Memon

Research output: Contribution to conferencePaperResearchpeer-review

Abstract

Objectives: The aim was to conduct a meta-analysis of randomised control trials (RCTs) investigating the treatment of gallstone pancreatitis (GSP) by early ERCP versus conservative management and subsequent patient outcomes.
Data Sources and Review Methods: A search of Medline, Embase, Science Citation Index, Current Contents, PubMed and the Cochrane Database of Randomised control trials identified all RCTs comparing early ERCP to conservative treatment in gallstone pancreatitis published in the English Language. The meta-analysis was prepared with reference to the guidelines given in the Quality of Reporting of Meta-analysis (QUOROM) statement. Variables that were considered the most objective to analyse were overall mortality, overall morbidity, severity of pancreatitis (mild or severe), pseudocyst formation, organ failure (renal, respiratory and cardiac), abnormal coagulation, development of pancreatic abscess/phlegmon and biliary sepsis.
Results: Six trials were identified totalling 997 patients. There were significantly fewer complications in the active treatment group OR 1.78 (1.19, 2.67) with two further variables (pseudocyst formation and biliary sepsis) strongly favouring treatment but not reaching statistical significance. The other outcome variables examined showed no strong trend for either treatment regimen.
Conclusions: Early ERCP in the setting of acute GSP significantly decreases the risk of complications and biliary sepsis.
Original languageEnglish
Pages98-105
Number of pages8
Publication statusPublished - 2010
EventTenth Islamic Countries Conference on Statistical Science: Statistics for development and good governance - Cairo, Egypt
Duration: 20 Dec 200923 Dec 2009
Conference number: 10
https://www.iccs-x.org.eg

Conference

ConferenceTenth Islamic Countries Conference on Statistical Science
CountryEgypt
CityCairo
Period20/12/0923/12/09
Internet address

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Endoscopic Retrograde Cholangiopancreatography
Gallstones
Pancreatitis
Meta-Analysis
Sepsis
Cellulitis
Information Storage and Retrieval
Therapeutics
PubMed
Respiratory Insufficiency
Abscess
Renal Insufficiency
Language
Heart Failure
Databases
Guidelines
Morbidity
Mortality
Conservative Treatment

Cite this

Burstow, M. J., Mohamad Yunus, R., Khan, S., Memon, B., & Memon, M. (2010). Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis. 98-105. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.
Burstow, Matthew John ; Mohamad Yunus, Rossita ; Khan, Shahjahan ; Memon, Breda ; Memon, Muhammed. / Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.8 p.
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abstract = "Objectives: The aim was to conduct a meta-analysis of randomised control trials (RCTs) investigating the treatment of gallstone pancreatitis (GSP) by early ERCP versus conservative management and subsequent patient outcomes.Data Sources and Review Methods: A search of Medline, Embase, Science Citation Index, Current Contents, PubMed and the Cochrane Database of Randomised control trials identified all RCTs comparing early ERCP to conservative treatment in gallstone pancreatitis published in the English Language. The meta-analysis was prepared with reference to the guidelines given in the Quality of Reporting of Meta-analysis (QUOROM) statement. Variables that were considered the most objective to analyse were overall mortality, overall morbidity, severity of pancreatitis (mild or severe), pseudocyst formation, organ failure (renal, respiratory and cardiac), abnormal coagulation, development of pancreatic abscess/phlegmon and biliary sepsis. Results: Six trials were identified totalling 997 patients. There were significantly fewer complications in the active treatment group OR 1.78 (1.19, 2.67) with two further variables (pseudocyst formation and biliary sepsis) strongly favouring treatment but not reaching statistical significance. The other outcome variables examined showed no strong trend for either treatment regimen.Conclusions: Early ERCP in the setting of acute GSP significantly decreases the risk of complications and biliary sepsis.",
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Burstow, MJ, Mohamad Yunus, R, Khan, S, Memon, B & Memon, M 2010, 'Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis' Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt, 20/12/09 - 23/12/09, pp. 98-105.

Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis. / Burstow, Matthew John; Mohamad Yunus, Rossita; Khan, Shahjahan; Memon, Breda; Memon, Muhammed.

2010. 98-105 Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.

Research output: Contribution to conferencePaperResearchpeer-review

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T1 - Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis

AU - Burstow, Matthew John

AU - Mohamad Yunus, Rossita

AU - Khan, Shahjahan

AU - Memon, Breda

AU - Memon, Muhammed

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N2 - Objectives: The aim was to conduct a meta-analysis of randomised control trials (RCTs) investigating the treatment of gallstone pancreatitis (GSP) by early ERCP versus conservative management and subsequent patient outcomes.Data Sources and Review Methods: A search of Medline, Embase, Science Citation Index, Current Contents, PubMed and the Cochrane Database of Randomised control trials identified all RCTs comparing early ERCP to conservative treatment in gallstone pancreatitis published in the English Language. The meta-analysis was prepared with reference to the guidelines given in the Quality of Reporting of Meta-analysis (QUOROM) statement. Variables that were considered the most objective to analyse were overall mortality, overall morbidity, severity of pancreatitis (mild or severe), pseudocyst formation, organ failure (renal, respiratory and cardiac), abnormal coagulation, development of pancreatic abscess/phlegmon and biliary sepsis. Results: Six trials were identified totalling 997 patients. There were significantly fewer complications in the active treatment group OR 1.78 (1.19, 2.67) with two further variables (pseudocyst formation and biliary sepsis) strongly favouring treatment but not reaching statistical significance. The other outcome variables examined showed no strong trend for either treatment regimen.Conclusions: Early ERCP in the setting of acute GSP significantly decreases the risk of complications and biliary sepsis.

AB - Objectives: The aim was to conduct a meta-analysis of randomised control trials (RCTs) investigating the treatment of gallstone pancreatitis (GSP) by early ERCP versus conservative management and subsequent patient outcomes.Data Sources and Review Methods: A search of Medline, Embase, Science Citation Index, Current Contents, PubMed and the Cochrane Database of Randomised control trials identified all RCTs comparing early ERCP to conservative treatment in gallstone pancreatitis published in the English Language. The meta-analysis was prepared with reference to the guidelines given in the Quality of Reporting of Meta-analysis (QUOROM) statement. Variables that were considered the most objective to analyse were overall mortality, overall morbidity, severity of pancreatitis (mild or severe), pseudocyst formation, organ failure (renal, respiratory and cardiac), abnormal coagulation, development of pancreatic abscess/phlegmon and biliary sepsis. Results: Six trials were identified totalling 997 patients. There were significantly fewer complications in the active treatment group OR 1.78 (1.19, 2.67) with two further variables (pseudocyst formation and biliary sepsis) strongly favouring treatment but not reaching statistical significance. The other outcome variables examined showed no strong trend for either treatment regimen.Conclusions: Early ERCP in the setting of acute GSP significantly decreases the risk of complications and biliary sepsis.

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Burstow MJ, Mohamad Yunus R, Khan S, Memon B, Memon M. Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis. 2010. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.