Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis

Matthew John Burstow, Rossita Mohamad Yunus, Shahjahan Khan, Breda Memon, Muhammed Memon

Research output: Contribution to conferencePaperResearchpeer-review

Abstract

Objectives: The aim was to conduct a meta-analysis of randomised control trials (RCTs) investigating the treatment of gallstone pancreatitis (GSP) by early ERCP versus conservative management and subsequent patient outcomes.
Data Sources and Review Methods: A search of Medline, Embase, Science Citation Index, Current Contents, PubMed and the Cochrane Database of Randomised control trials identified all RCTs comparing early ERCP to conservative treatment in gallstone pancreatitis published in the English Language. The meta-analysis was prepared with reference to the guidelines given in the Quality of Reporting of Meta-analysis (QUOROM) statement. Variables that were considered the most objective to analyse were overall mortality, overall morbidity, severity of pancreatitis (mild or severe), pseudocyst formation, organ failure (renal, respiratory and cardiac), abnormal coagulation, development of pancreatic abscess/phlegmon and biliary sepsis.
Results: Six trials were identified totalling 997 patients. There were significantly fewer complications in the active treatment group OR 1.78 (1.19, 2.67) with two further variables (pseudocyst formation and biliary sepsis) strongly favouring treatment but not reaching statistical significance. The other outcome variables examined showed no strong trend for either treatment regimen.
Conclusions: Early ERCP in the setting of acute GSP significantly decreases the risk of complications and biliary sepsis.
Original languageEnglish
Pages98-105
Number of pages8
Publication statusPublished - 2010
EventTenth Islamic Countries Conference on Statistical Science: Statistics for development and good governance - Cairo, Egypt
Duration: 20 Dec 200923 Dec 2009
Conference number: 10
https://www.iccs-x.org.eg

Conference

ConferenceTenth Islamic Countries Conference on Statistical Science
CountryEgypt
CityCairo
Period20/12/0923/12/09
Internet address

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    Burstow, M. J., Mohamad Yunus, R., Khan, S., Memon, B., & Memon, M. (2010). Preliminary results of meta-analysis of endoscopic retrograde cholangiopancreatography (ERCP) versus conservative treatment for gall stone pancreatitis. 98-105. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.