Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery

Emma J Osland, Belal Hossain, Shahjahan Khan, Muhammed Memon

Research output: Contribution to conferencePaperResearchpeer-review

Abstract

Extract: Providing tube feeds or liquid oral supplements containing additional arginine and/or omega-3 fatty acids and RNA - often referred to as 'immunonutrition' and more recently 'pharmaconutrition' - has been proposed as a strategy to decrease postoperative complications and duration of hospital length of stay for elective surgical patients. However outcomes of individual studies vary and the purported benefits remain controversial. A meta-analysis on this topic was recently published (Zheng et al., 2007), however further randomised controlled trials on this topic have appeared in the literature since this time. This meta-analysis has been undertaken to update the previously published meta-analysis and to attempt to elucidate the potential benefit of providing immune-enhanced nutrition in surgical patients. A search of electronic databases identified all RCTs comparing the use of pre and/or perioperative immunonutrition with standard nutrition provision in elective adult surgical patients between 1990 and 2008. The meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses (QUOROM) statement. The variables analysed included mortality, total complications, infective complications, anastomotic leak (where applicable), and length of hospital stay. 20 distinct studies were identified that met inclusion criteria involving 1966 patients (immunonutrition n= 1048; standard nutrition n= 918).
Original languageEnglish
Pages132-139
Number of pages8
Publication statusPublished - 2010
EventTenth Islamic Countries Conference on Statistical Science: Statistics for development and good governance - Cairo, Egypt
Duration: 20 Dec 200923 Dec 2009
Conference number: 10
https://www.iccs-x.org.eg

Conference

ConferenceTenth Islamic Countries Conference on Statistical Science
CountryEgypt
CityCairo
Period20/12/0923/12/09
Internet address

Fingerprint

Meta-Analysis
Length of Stay
Anastomotic Leak
Omega-3 Fatty Acids
Arginine
Randomized Controlled Trials
Outcome Assessment (Health Care)
Databases
RNA
Mortality

Cite this

Osland, E. J., Hossain, B., Khan, S., & Memon, M. (2010). Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery. 132-139. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.
Osland, Emma J ; Hossain, Belal ; Khan, Shahjahan ; Memon, Muhammed. / Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.8 p.
@conference{cd870d89da514884a7c99be0805c49ae,
title = "Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery",
abstract = "Extract: Providing tube feeds or liquid oral supplements containing additional arginine and/or omega-3 fatty acids and RNA - often referred to as 'immunonutrition' and more recently 'pharmaconutrition' - has been proposed as a strategy to decrease postoperative complications and duration of hospital length of stay for elective surgical patients. However outcomes of individual studies vary and the purported benefits remain controversial. A meta-analysis on this topic was recently published (Zheng et al., 2007), however further randomised controlled trials on this topic have appeared in the literature since this time. This meta-analysis has been undertaken to update the previously published meta-analysis and to attempt to elucidate the potential benefit of providing immune-enhanced nutrition in surgical patients. A search of electronic databases identified all RCTs comparing the use of pre and/or perioperative immunonutrition with standard nutrition provision in elective adult surgical patients between 1990 and 2008. The meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses (QUOROM) statement. The variables analysed included mortality, total complications, infective complications, anastomotic leak (where applicable), and length of hospital stay. 20 distinct studies were identified that met inclusion criteria involving 1966 patients (immunonutrition n= 1048; standard nutrition n= 918).",
author = "Osland, {Emma J} and Belal Hossain and Shahjahan Khan and Muhammed Memon",
year = "2010",
language = "English",
pages = "132--139",
note = "Tenth Islamic Countries Conference on Statistical Science : Statistics for development and good governance ; Conference date: 20-12-2009 Through 23-12-2009",
url = "https://www.iccs-x.org.eg",

}

Osland, EJ, Hossain, B, Khan, S & Memon, M 2010, 'Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery' Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt, 20/12/09 - 23/12/09, pp. 132-139.

Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery. / Osland, Emma J; Hossain, Belal; Khan, Shahjahan; Memon, Muhammed.

2010. 132-139 Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.

Research output: Contribution to conferencePaperResearchpeer-review

TY - CONF

T1 - Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery

AU - Osland, Emma J

AU - Hossain, Belal

AU - Khan, Shahjahan

AU - Memon, Muhammed

PY - 2010

Y1 - 2010

N2 - Extract: Providing tube feeds or liquid oral supplements containing additional arginine and/or omega-3 fatty acids and RNA - often referred to as 'immunonutrition' and more recently 'pharmaconutrition' - has been proposed as a strategy to decrease postoperative complications and duration of hospital length of stay for elective surgical patients. However outcomes of individual studies vary and the purported benefits remain controversial. A meta-analysis on this topic was recently published (Zheng et al., 2007), however further randomised controlled trials on this topic have appeared in the literature since this time. This meta-analysis has been undertaken to update the previously published meta-analysis and to attempt to elucidate the potential benefit of providing immune-enhanced nutrition in surgical patients. A search of electronic databases identified all RCTs comparing the use of pre and/or perioperative immunonutrition with standard nutrition provision in elective adult surgical patients between 1990 and 2008. The meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses (QUOROM) statement. The variables analysed included mortality, total complications, infective complications, anastomotic leak (where applicable), and length of hospital stay. 20 distinct studies were identified that met inclusion criteria involving 1966 patients (immunonutrition n= 1048; standard nutrition n= 918).

AB - Extract: Providing tube feeds or liquid oral supplements containing additional arginine and/or omega-3 fatty acids and RNA - often referred to as 'immunonutrition' and more recently 'pharmaconutrition' - has been proposed as a strategy to decrease postoperative complications and duration of hospital length of stay for elective surgical patients. However outcomes of individual studies vary and the purported benefits remain controversial. A meta-analysis on this topic was recently published (Zheng et al., 2007), however further randomised controlled trials on this topic have appeared in the literature since this time. This meta-analysis has been undertaken to update the previously published meta-analysis and to attempt to elucidate the potential benefit of providing immune-enhanced nutrition in surgical patients. A search of electronic databases identified all RCTs comparing the use of pre and/or perioperative immunonutrition with standard nutrition provision in elective adult surgical patients between 1990 and 2008. The meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses (QUOROM) statement. The variables analysed included mortality, total complications, infective complications, anastomotic leak (where applicable), and length of hospital stay. 20 distinct studies were identified that met inclusion criteria involving 1966 patients (immunonutrition n= 1048; standard nutrition n= 918).

M3 - Paper

SP - 132

EP - 139

ER -

Osland EJ, Hossain B, Khan S, Memon M. Preliminary results of a meta-analysis evaluating the effect of immunonutrition on outcomes of elective gastrointestinal surgery. 2010. Paper presented at Tenth Islamic Countries Conference on Statistical Science, Cairo, Egypt.