Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: A meta-analysis of individual patient data

Maroeska M. Rovers, Paul Glasziou, Cees L. Appelman, Peter Burke, David P. McCormick, Roger A. Damoiseaux, Paul Little, Nicole Le Saux, Arno W. Hoes

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

OBJECTIVE. The goal was to determine the predictors of a prolonged course for children with acute otitis media.

METHODS. A meta- analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/ or pain at 3 to 7 days.

RESULTS. Of the 824 included children, 303 had pain and/ or fever at 3 to 7 days. Independent predictors of a prolonged course were age of <2 years and bilateral acute otitis media. The absolute risk of pain and/ or fever at 3 to 7 days for children <2 years of age with bilateral acute otitis media ( 20% of all children) was 55%, and that for children >= 2 years of age with unilateral acute otitis media ( 47% of all children) was 25%.

CONCLUSIONS. The risk of a prolonged course was 2 times higher for children <2 years of age with bilateral acute otitis media than for children <2 years of age with unilateral acute otitis media. Clinicians can use these features ( ie, age of >= 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalPediatrics
Volume119
Issue number3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

Cite this

Rovers, Maroeska M. ; Glasziou, Paul ; Appelman, Cees L. ; Burke, Peter ; McCormick, David P. ; Damoiseaux, Roger A. ; Little, Paul ; Le Saux, Nicole ; Hoes, Arno W. / Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics : A meta-analysis of individual patient data. In: Pediatrics. 2007 ; Vol. 119, No. 3. pp. 579-585.
@article{d9b80363e4294c59bc2ac798991335f0,
title = "Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: A meta-analysis of individual patient data",
abstract = "OBJECTIVE. The goal was to determine the predictors of a prolonged course for children with acute otitis media.METHODS. A meta- analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/ or pain at 3 to 7 days.RESULTS. Of the 824 included children, 303 had pain and/ or fever at 3 to 7 days. Independent predictors of a prolonged course were age of <2 years and bilateral acute otitis media. The absolute risk of pain and/ or fever at 3 to 7 days for children <2 years of age with bilateral acute otitis media ( 20{\%} of all children) was 55{\%}, and that for children >= 2 years of age with unilateral acute otitis media ( 47{\%} of all children) was 25{\%}.CONCLUSIONS. The risk of a prolonged course was 2 times higher for children <2 years of age with bilateral acute otitis media than for children <2 years of age with unilateral acute otitis media. Clinicians can use these features ( ie, age of >= 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child.",
author = "Rovers, {Maroeska M.} and Paul Glasziou and Appelman, {Cees L.} and Peter Burke and McCormick, {David P.} and Damoiseaux, {Roger A.} and Paul Little and {Le Saux}, Nicole and Hoes, {Arno W.}",
year = "2007",
month = "3",
doi = "10.1542/peds.2006-2092",
language = "English",
volume = "119",
pages = "579--585",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "AMER ACAD PEDIATRICS",
number = "3",

}

Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics : A meta-analysis of individual patient data. / Rovers, Maroeska M.; Glasziou, Paul; Appelman, Cees L.; Burke, Peter; McCormick, David P.; Damoiseaux, Roger A.; Little, Paul; Le Saux, Nicole; Hoes, Arno W.

In: Pediatrics, Vol. 119, No. 3, 03.2007, p. 579-585.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics

T2 - A meta-analysis of individual patient data

AU - Rovers, Maroeska M.

AU - Glasziou, Paul

AU - Appelman, Cees L.

AU - Burke, Peter

AU - McCormick, David P.

AU - Damoiseaux, Roger A.

AU - Little, Paul

AU - Le Saux, Nicole

AU - Hoes, Arno W.

PY - 2007/3

Y1 - 2007/3

N2 - OBJECTIVE. The goal was to determine the predictors of a prolonged course for children with acute otitis media.METHODS. A meta- analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/ or pain at 3 to 7 days.RESULTS. Of the 824 included children, 303 had pain and/ or fever at 3 to 7 days. Independent predictors of a prolonged course were age of <2 years and bilateral acute otitis media. The absolute risk of pain and/ or fever at 3 to 7 days for children <2 years of age with bilateral acute otitis media ( 20% of all children) was 55%, and that for children >= 2 years of age with unilateral acute otitis media ( 47% of all children) was 25%.CONCLUSIONS. The risk of a prolonged course was 2 times higher for children <2 years of age with bilateral acute otitis media than for children <2 years of age with unilateral acute otitis media. Clinicians can use these features ( ie, age of >= 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child.

AB - OBJECTIVE. The goal was to determine the predictors of a prolonged course for children with acute otitis media.METHODS. A meta- analysis of data with the observation groups of 6 randomized, controlled trials was performed. Participants were 824 children, 6 months to 12 years of age, with acute otitis media. The primary outcome was a prolonged course of acute otitis media, which was defined as fever and/ or pain at 3 to 7 days.RESULTS. Of the 824 included children, 303 had pain and/ or fever at 3 to 7 days. Independent predictors of a prolonged course were age of <2 years and bilateral acute otitis media. The absolute risk of pain and/ or fever at 3 to 7 days for children <2 years of age with bilateral acute otitis media ( 20% of all children) was 55%, and that for children >= 2 years of age with unilateral acute otitis media ( 47% of all children) was 25%.CONCLUSIONS. The risk of a prolonged course was 2 times higher for children <2 years of age with bilateral acute otitis media than for children <2 years of age with unilateral acute otitis media. Clinicians can use these features ( ie, age of >= 2 years and bilateral acute otitis media) to inform parents more explicitly about the expected course of their child's otitis media and to explain which features should prompt parents to contact their clinician for reexamination of the child.

U2 - 10.1542/peds.2006-2092

DO - 10.1542/peds.2006-2092

M3 - Article

VL - 119

SP - 579

EP - 585

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 3

ER -