Polyphenols as novel interventions for depression: Exploring the efficacy, mechanisms of action, and implications for future research

Elizabeth Gamage*, Rebecca Orr, Nikolaj Travica, Melissa M Lane, Thusharika Dissanayaka, Jee Hyun Kim, Giuseppe Grosso, Justyna Godos, Wolfgang Marx

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)
63 Downloads (Pure)

Abstract

Numerous animal and human studies have assessed the relationship between polyphenols and outcomes related to depression. However, no comprehensive synthesis of the main findings has been conducted. The aim of this manuscript was to systematically review the available evidence from animal and human studies on the association and the effects of dietary polyphenols on depression and provide recommendations for future research. We based our review on 163 preclinical animal, 16 observational and 44 intervention articles assessing the relationship between polyphenols and outcomes related to depression. Most animal studies demonstrated that exposure to polyphenols alleviated behaviours reported to be associated with depression. However, human studies are less clear, with some studies reporting an inverse relationship between the intake of some polyphenols, and polyphenol rich foods and depression risk and symptoms, while others reporting no association or effect. Hence, while there has been extensive research conducted in animals and there is some supporting evidence in humans, further human studies are required, particularly in younger and clinical populations.

Original languageEnglish
Article number105225
Pages (from-to)1-24
Number of pages24
JournalNeuroscience and Biobehavioral Reviews
Volume151
DOIs
Publication statusPublished - Aug 2023
Externally publishedYes

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