Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response

Gerwyn Morris, Elizabeth Gamage, Nikolaj Travica, Michael Berk, Felice N. Jacka, Adrienne O'Neil, Basant K. Puri, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder, Wolfgang Marx*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)

Abstract

The pathophysiology of psychiatric and neurodegenerative disorders is complex and multifactorial. Polyphenols possess a range of potentially beneficial mechanisms of action that relate to the implicated pathways in psychiatric and neurodegenerative disorders. The aim of this review is to highlight the emerging clinical trial and preclinical efficacy data regarding the role of polyphenols in mental and brain health, elucidate novel mechanisms of action including the gut microbiome and gene expression, and discuss the factors that may be responsible for the mixed clinical results; namely, the role of interindividual differences in treatment response and the potentially pro-oxidant effects of some polyphenols. Further clarification as part of larger, well conducted randomized controlled trials that incorporate precision medicine methods are required to inform clinical efficacy and optimal dosing regimens.

Original languageEnglish
Pages (from-to)101-122
Number of pages22
JournalFree Radical Biology and Medicine
Volume172
DOIs
Publication statusPublished - 20 Aug 2021
Externally publishedYes

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