Phasic contractions of the pig bladder: Functional heterogeneity between bladder regions and the role of the mucosa

Helen Nyamwaro, Neil G. McKay, Kim Lawson, Christopher R. Chapple, Donna J Sellers

Research output: Contribution to journalMeeting AbstractResearchpeer-review


OAB, a LUT disorder defined by the ICS as urinary urgency with or without incontinence, is characterised by increased spontaneous or phasic bladder contractions (PCs) which are thought to originate from the mucosa, although the exact mechanism involved is still unclear. Immunohistological studies by Gillespie et al (2004a,b;2005) have shown possible heterogeneity of the urotheliumand suburothelial myofibroblasts between the trigone,lateral wall and dome of the bladder. The aim of the present study was to determine any functional heterogeneity in PCsin these bladder regions and the role of the mucosa.
Original languageEnglish
Article number123
Pages (from-to)71-71
Number of pages1
JournalEuropean Urology, Supplements
Issue number2
Publication statusPublished - 2010
Externally publishedYes


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