Pharmacotherapy of persons with dementia in long-term care in australia: A descriptive audit of central nervous system medications

Wendy Moyle, Najwan El Saifi, Brian Draper, Cindy Jones, Elizabeth Beattie, David Shum, Lukman Thalib, Cindy Mervin, Siobhan O’Dwyer

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Background: Neuropsychiatric symptoms of dementia are often treated through the prescription of one or more psychotropic medications. However, limited efficacy and potential harmful side-effects has resulted in efforts to reduce the use of psychotropic medication in this population, particularly for those living in long-term care. Objectives: This study sought to describe the pattern of central nervous system medication usage in older adults with dementia living in long-term care; assess the appropriateness of prescribing against Beers criteria; and detect potential drug interactions from co-administered medications. Methods: A retrospective descriptive audit of the medical records of n=415 residents, aged >60 years with a diagnosis of dementia, from 28 long-term care facilities in Queensland, Australia. Information extracted included the types and usage of regular and Pro Re Nata central nervous system medications. Results: Of those taking medication (n=317), 68% were prescribed at least one potentially inappropriate medication, and there was a significant positive correlation between the number of medications prescribed and the number of potentially inappropriate medications. Two-hundred potential interactions with variable severity were identified from 130 residents on ≥1 medication – 38% were potentially severe interactions, 46% were moderate. Conclusion: This medication audit raises concerns that prescription of medications may still be the first resort to treat behavioural and psychological symptoms of dementia. There is a need for effective and sustainable person-centred interventions that address barriers for appropriate prescribing practice, and involve the collaboration of all healthcare professionals to optimise prescribing and improve the quality of medicines in older people with dementia.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalCurrent Drug Safety
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Jul 2017
Externally publishedYes

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Drug therapy
Neurology
Long-Term Care
Dementia
Central Nervous System
Drug interactions
Drug Therapy
Medicine
Prescriptions
Behavioral Symptoms
Queensland
Drug Interactions
Medical Records
Psychology
Delivery of Health Care
Population
Potentially Inappropriate Medication List

Cite this

Moyle, Wendy ; El Saifi, Najwan ; Draper, Brian ; Jones, Cindy ; Beattie, Elizabeth ; Shum, David ; Thalib, Lukman ; Mervin, Cindy ; O’Dwyer, Siobhan. / Pharmacotherapy of persons with dementia in long-term care in australia : A descriptive audit of central nervous system medications. In: Current Drug Safety. 2017 ; Vol. 12, No. 2. pp. 95-102.
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Pharmacotherapy of persons with dementia in long-term care in australia : A descriptive audit of central nervous system medications. / Moyle, Wendy; El Saifi, Najwan; Draper, Brian; Jones, Cindy; Beattie, Elizabeth; Shum, David; Thalib, Lukman; Mervin, Cindy; O’Dwyer, Siobhan.

In: Current Drug Safety, Vol. 12, No. 2, 01.07.2017, p. 95-102.

Research output: Contribution to journalArticleResearchpeer-review

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AU - El Saifi, Najwan

AU - Draper, Brian

AU - Jones, Cindy

AU - Beattie, Elizabeth

AU - Shum, David

AU - Thalib, Lukman

AU - Mervin, Cindy

AU - O’Dwyer, Siobhan

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