Patient-centered modular secondary prevention following acute coronary syndrome: A randomized controlled trial

J. Redfern*, T. Briffa, E. Ellis, S.B. Freedman

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)


Cardiac rehabilitation (CR) is beneficial for those who attend, but alternative models for nonattenders need investigation. We tested the effectiveness of modular prevention on risk factors in survivors of acute coronary syndrome (ACS) not accessing CR.

We randomly allocated ACS survivors not accessing CR to a control group (n = 72) receiving conventional care or modular group (n = 72) who participated in risk factor modules on the basis of patient-centered care and collaborative goal setting to systematically lower risk factors. We also recruited a consecutive reference group of ACS survivors participating in CR (n = 64). Blinded measurements of risk factors and global risk were completed at baseline and 3 months.

Although well matched for risk factor level and prevalence at baseline, by 3 months, the modular group had significantly reduced risk factor level in comparison with controls for most risk factors including total cholesterol (158 ± 3.9 vs 186 ± 3.9 mg/dL, P < .001), systolic blood pressure (133.5 ± 2.0 vs 144.4 ± 2.4 mm Hg, P < .01), body mass index (28.9 ± 0.7 vs 31.0 ± 0.7 kg/m2, P = .02), and physical activity (1,187 ± 164 vs 636 ± 115 metabolic equivalents [METS]/kg/min, P < .01). Also at 3 months, fewer patients in the modular group smoked than in the control group (6% vs 23%, P < .01) and were in the moderate to high-risk category of the Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) score (40% vs 59%, P = .02). Although the modular group had higher risk factors at baseline, they achieved similar mean levels as the CR group at 3 months.

Patient-centered modular prevention significantly improves coronary risk profile in comparison with conventional care and provides an effective alternative for the large numbers of ACS survivors not accessing CR.
Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Issue number2
Publication statusPublished - Mar 2008
Externally publishedYes


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