TY - JOUR
T1 - Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis
AU - Singhabahu, Rachitha
AU - Gamage, SMK
AU - Gopalan, Vinod
PY - 2023/4/13
Y1 - 2023/4/13
N2 - The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.
AB - The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.
U2 - https://doi.org/10.1016/j.cpt.2023.04.001
DO - https://doi.org/10.1016/j.cpt.2023.04.001
M3 - Article
SN - 2949-7132
SP - 1
EP - 9
JO - Cancer Pathogenesis and Therapy
JF - Cancer Pathogenesis and Therapy
ER -
