Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

Rachitha Singhabahu; Sujani M Kodagoda Gamage; Vinod Gopalan

doi:10.1016/j.cpt.2023.04.001

Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

Rachitha Singhabahu, Sujani M Kodagoda Gamage, Vinod Gopalan^*

^*Corresponding author for this work

Faculty of Health Sciences & Medicine

Research output: Contribution to journal › Review article › Research › peer-review

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Abstract

The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.

Original language	English
Pages (from-to)	65-73
Number of pages	9
Journal	Cancer Pathogenesis and Therapy
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.cpt.2023.04.001
Publication status	Published - Apr 2024

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Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesisFinal published version, 1.15 MBLicence: CC BY-NC-ND

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title = "Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis",

abstract = "The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.",

author = "Rachitha Singhabahu and {Kodagoda Gamage}, {Sujani M} and Vinod Gopalan",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2024",

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doi = "10.1016/j.cpt.2023.04.001",

language = "English",

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T1 - Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

AU - Singhabahu, Rachitha

AU - Kodagoda Gamage, Sujani M

AU - Gopalan, Vinod

PY - 2024/4

Y1 - 2024/4

N2 - The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.

AB - The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.

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DO - 10.1016/j.cpt.2023.04.001

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JO - Cancer Pathogenesis and Therapy

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Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

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