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Abstract
Background:
Adults with obesity are electing bariatric procedures
including the laparoscopic sleeve gastrectomy (LSG) and more
recently, the incisionless endoscopic sleeve gastroplasty (ESG).
However, their efficacy, safety and patient-centered outcomes re-
quire further investigation in the Australian setting. To examine the
6- and 12-month weight loss efficacy, safety, and weight-related
quality of life (QoL) of adults with obesity who received the ESG
or LSG bariatric procedure with 12+ months of adjuvant multidisci-
plinary pre- and postoperative support.
Methods:
Two-arm prospective cohort study followed Australian
patients who elected the ESG or LSG procedure from baseline to
12-months postoperative. Excess weight loss (EWL) was the primary
outcome. Secondary outcomes were body composition via dual en-
ergy X-ray absorptiometry, weight-related QoL, lipid, glycemic, and
hepatic biochemistry, and adverse events.
Results:
16 (81.2% female; aged 41.4 (SD = 10.4)years; BMI = 35.5 (SD
= 5.2)kg/m2) ESG and 45 (84.4% female; aged 40.4 (9.0)years; BMI =
40.7 (5.6)kg/m2) LSG participants were recruited. At 12-months post-
procedure, ESG EWL was 57% (SD: 32%; p < 0.01) and LSG EWL was
79% (SD: 24; p < 0.001). ESG and LSG cohorts improved QoL, liver
function, and lipid profiles; however, only LSG was statistically signif-
icant (p < 0.001). Both cohorts reduced fat mass (p < 0.05). The ESG
maintained but LSG decreased fat free mass at 6-months (p < 0.05). No
procedure-related serious adverse events were identified.
Conclusions:
In this setting, the ESG and LSG were safe and effective
weight loss treatments for obese adults alongside multidisciplinary sup-
port. The ESG may confer additional benefits in the retention of fat free
mass whilst LSG may lead to greater overall (fat and fat-free mass) weight
loss. Further well powered studies are required to confirm these findings.
Adults with obesity are electing bariatric procedures
including the laparoscopic sleeve gastrectomy (LSG) and more
recently, the incisionless endoscopic sleeve gastroplasty (ESG).
However, their efficacy, safety and patient-centered outcomes re-
quire further investigation in the Australian setting. To examine the
6- and 12-month weight loss efficacy, safety, and weight-related
quality of life (QoL) of adults with obesity who received the ESG
or LSG bariatric procedure with 12+ months of adjuvant multidisci-
plinary pre- and postoperative support.
Methods:
Two-arm prospective cohort study followed Australian
patients who elected the ESG or LSG procedure from baseline to
12-months postoperative. Excess weight loss (EWL) was the primary
outcome. Secondary outcomes were body composition via dual en-
ergy X-ray absorptiometry, weight-related QoL, lipid, glycemic, and
hepatic biochemistry, and adverse events.
Results:
16 (81.2% female; aged 41.4 (SD = 10.4)years; BMI = 35.5 (SD
= 5.2)kg/m2) ESG and 45 (84.4% female; aged 40.4 (9.0)years; BMI =
40.7 (5.6)kg/m2) LSG participants were recruited. At 12-months post-
procedure, ESG EWL was 57% (SD: 32%; p < 0.01) and LSG EWL was
79% (SD: 24; p < 0.001). ESG and LSG cohorts improved QoL, liver
function, and lipid profiles; however, only LSG was statistically signif-
icant (p < 0.001). Both cohorts reduced fat mass (p < 0.05). The ESG
maintained but LSG decreased fat free mass at 6-months (p < 0.05). No
procedure-related serious adverse events were identified.
Conclusions:
In this setting, the ESG and LSG were safe and effective
weight loss treatments for obese adults alongside multidisciplinary sup-
port. The ESG may confer additional benefits in the retention of fat free
mass whilst LSG may lead to greater overall (fat and fat-free mass) weight
loss. Further well powered studies are required to confirm these findings.
| Original language | English |
|---|---|
| Article number | Poster 218 |
| Pages (from-to) | 134-134 |
| Number of pages | 1 |
| Journal | Obesity |
| Volume | 29 |
| Publication status | Published - 1 Nov 2023 |
| Event | Obesity Week 2023 - Florida, United States Duration: 14 Oct 2023 → 17 Oct 2023 https://obesityweek.org/ |
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Dive into the research topics of 'Outcomes of ESG and LSG with 12+ Months of Adjuvant Pre- and Postoperative Multidisciplinary Support'. Together they form a unique fingerprint.Related Projects
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Nutrition to optimise surgical outcomes
Marshall, S., Reidlinger, D., O'Neill, H., Isenring, E., Van der Meij, B., Tang, X., Campbell, K. & Kelly, J.
1/01/18 → 30/06/26
Project: Research
Related Research Outputs
- 1 Abstract
-
Outcomes of ESG and LSG with 12+ Months of Adjuvant Pre- and Postoperative Multidisciplinary Support
Marshall, S., Carr, P., Keighley, T., Petocz, P., Rich, G., Cohen, F., Soni, A., Maimone, I. R., Fayet-Moore, F. & Isenring, E., Nov 2021, (E-pub ahead of print).Research output: Contribution to conference › Abstract › Research › peer-review
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