One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine

Matthew Links, Peter Galettis

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review


Drug dosing is based on the premise that the amount of drug given influences the toxicity and response. The premise of pharmacokinetics is that it is not the amount of drug given, but the amount the patient is exposed to, that determines drug effect. Measurements of drug exposure are usually performed by determining the concentration in serum or plasma. This accounts for variability in drug clearance in determining the patient’s exposure. This has resulted in such dosing strategies as carboplatin dosing based on creatinine clearance, therapeutic dose monitoring of methotrexate and pharmacogenetically modified dosing for irinotecan.
Original languageEnglish
Title of host publicationReadings in Advanced Pharmacokinetics
EditorsAyman Noreddin
Number of pages22
ISBN (Electronic)9789535169734
ISBN (Print)9789535105336
Publication statusPublished - 20 Apr 2012
Externally publishedYes


Dive into the research topics of 'One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine'. Together they form a unique fingerprint.

Cite this