1. Omeprazole, a substituted benzimidazole and a potent gastric antisecretory drug has been tested for inhibition of microsomal drug oxidative function in the rat.
2. A single dose of 40 mg/kg prolonged pentobarbitone sleeping times from 118 (range 73–168) min to 195 (159–222) min (P < 0.01), pentobarbitone half‐lives from 89 (63–114) to 112 (54–146) min (P < 0.05) and aminopyrine breath 14CO2 half‐lives from 43 (37–51) to 56 (49–79) min (P < 0.05). Omeprazole in doses of 20 mg/kg or less had no significant effect.
3. In prolonging pentobarbitone sleeping times omeprazole 40 mg/kg and an equimolar (30 mg/kg) dose of cimetidine were approximately equipotent.
4. These results contrast with studies in man in which much smaller doses of omeprazole have been shown to produce clinically significant inhibition of drug metabolism.
|Number of pages||5|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|Publication status||Published - May 1986|