Nutrition during trimodality treatment in stage III non-small cell lung cancer: Not only important for underweight patients

Barbara S van der Meij, Erik C J Phernambucq, Geert M Fieten, Egbert F Smit, Marinus A Paul, Paul A M van Leeuwen, J Wolter A Oosterhuis

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Abstract

INTRODUCTION: Trimodality treatment for stage III non-small cell lung cancer (NSCLC), consisting of chemoradiotherapy followed by surgery, is associated with treatment-related toxicity, malnutrition, and postoperative complications. The aim of this retrospective study was to investigate the predictive value of nutritional parameters on postoperative morbidity, mortality, and survival.

METHODS: Patients with stage III NSCLC undergoing concurrent chemoradiotherapy followed by surgery in one center between 2003 and 2009 were included. Age, sex, forced expiratory volume in 1 second, body mass index, weight change, and surgical and pathological factors were recorded and related to the occurrence of postoperative complications/mortality, overall survival (OS), and progression-free survival.

RESULTS: Of 51 study patients, 17 (33%) had overweight (body mass index ≥ 25) at start of treatment and 20 patients (39%) were malnourished at hospital admission for surgery. Postoperative complications occurred in 25 patients (49%), 6 had major complications, and 2 died within 90 days after surgery, but no significant predictive factors were found. Overall, weight loss ≥5% during induction period was associated with shorter OS (p = 0.03), but especially overweight patients experiencing weight loss ≥5% during induction period (n = 7) had shorter OS (hazard ratio 4.63, p = 0.005; log-rank p = 0.04) and progression-free survival (hazard ratio 6.03, p = 0.007).

CONCLUSIONS: This study indicates that malnutrition especially in overweight patients negatively influences survival outcomes of trimodality treatment for stage III NSCLC.

Original languageEnglish
Pages (from-to)1563-8
Number of pages6
JournalJournal of Thoracic Oncology
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

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    Cite this

    van der Meij, B. S., Phernambucq, E. C. J., Fieten, G. M., Smit, E. F., Paul, M. A., van Leeuwen, P. A. M., & Oosterhuis, J. W. A. (2011). Nutrition during trimodality treatment in stage III non-small cell lung cancer: Not only important for underweight patients. Journal of Thoracic Oncology, 6(9), 1563-8. https://doi.org/10.1097/JTO.0b013e3182208e90