Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study

Suetonia C Palmer, Marinella Ruospo, Katrina L Campbell, Vanessa Garcia Larsen, Valeria Saglimbene, Patrizia Natale, Letizia Gargano, Jonathan C Craig, David W Johnson, Marcello Tonelli, John Knight, Anna Bednarek-Skublewska, Eduardo Celia, Domingo Del Castillo, Jan Dulawa, Tevfik Ecder, Elisabeth Fabricius, João Miguel Frazão, Ruben Gelfman, Susanne Hildegard Hoischen & 8 others Staffan Schön, Paul Stroumza, Delia Timofte, Marietta Török, Jörgen Hegbrant, Charlotta Wollheim, Luc Frantzen, G F M Strippoli

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Abstract

INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.

METHODS AND ANALYSIS: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.

ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

Original languageEnglish
Article numbere006897
JournalBMJ Open
Volume5
Issue number3
DOIs
Publication statusPublished - 20 Mar 2015
Externally publishedYes

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Chronic Renal Insufficiency
Renal Dialysis
Dialysis
Hospitalization
Cohort Studies
Mortality
Health
Chronic Kidney Failure
Pragmatic Clinical Trials
Romania
Ethics Committees
Portugal
Hungary
Argentina
Kidney Diseases
Poland
Turkey
Informed Consent
Unsaturated Fatty Acids
Sweden

Cite this

Palmer, Suetonia C ; Ruospo, Marinella ; Campbell, Katrina L ; Garcia Larsen, Vanessa ; Saglimbene, Valeria ; Natale, Patrizia ; Gargano, Letizia ; Craig, Jonathan C ; Johnson, David W ; Tonelli, Marcello ; Knight, John ; Bednarek-Skublewska, Anna ; Celia, Eduardo ; Del Castillo, Domingo ; Dulawa, Jan ; Ecder, Tevfik ; Fabricius, Elisabeth ; Frazão, João Miguel ; Gelfman, Ruben ; Hoischen, Susanne Hildegard ; Schön, Staffan ; Stroumza, Paul ; Timofte, Delia ; Török, Marietta ; Hegbrant, Jörgen ; Wollheim, Charlotta ; Frantzen, Luc ; Strippoli, G F M. / Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis : protocol for DIET-HD, a prospective multinational cohort study. In: BMJ Open. 2015 ; Vol. 5, No. 3.
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abstract = "INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15{\%} and 20{\%} each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the {"}DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study,{"} a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.METHODS AND ANALYSIS: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.",
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Palmer, SC, Ruospo, M, Campbell, KL, Garcia Larsen, V, Saglimbene, V, Natale, P, Gargano, L, Craig, JC, Johnson, DW, Tonelli, M, Knight, J, Bednarek-Skublewska, A, Celia, E, Del Castillo, D, Dulawa, J, Ecder, T, Fabricius, E, Frazão, JM, Gelfman, R, Hoischen, SH, Schön, S, Stroumza, P, Timofte, D, Török, M, Hegbrant, J, Wollheim, C, Frantzen, L & Strippoli, GFM 2015, 'Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study' BMJ Open, vol. 5, no. 3, e006897. https://doi.org/10.1136/bmjopen-2014-006897

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis : protocol for DIET-HD, a prospective multinational cohort study. / Palmer, Suetonia C; Ruospo, Marinella; Campbell, Katrina L; Garcia Larsen, Vanessa; Saglimbene, Valeria; Natale, Patrizia; Gargano, Letizia; Craig, Jonathan C; Johnson, David W; Tonelli, Marcello; Knight, John; Bednarek-Skublewska, Anna; Celia, Eduardo; Del Castillo, Domingo; Dulawa, Jan; Ecder, Tevfik; Fabricius, Elisabeth; Frazão, João Miguel; Gelfman, Ruben; Hoischen, Susanne Hildegard; Schön, Staffan; Stroumza, Paul; Timofte, Delia; Török, Marietta; Hegbrant, Jörgen; Wollheim, Charlotta; Frantzen, Luc; Strippoli, G F M.

In: BMJ Open, Vol. 5, No. 3, e006897, 20.03.2015.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis

T2 - protocol for DIET-HD, a prospective multinational cohort study

AU - Palmer, Suetonia C

AU - Ruospo, Marinella

AU - Campbell, Katrina L

AU - Garcia Larsen, Vanessa

AU - Saglimbene, Valeria

AU - Natale, Patrizia

AU - Gargano, Letizia

AU - Craig, Jonathan C

AU - Johnson, David W

AU - Tonelli, Marcello

AU - Knight, John

AU - Bednarek-Skublewska, Anna

AU - Celia, Eduardo

AU - Del Castillo, Domingo

AU - Dulawa, Jan

AU - Ecder, Tevfik

AU - Fabricius, Elisabeth

AU - Frazão, João Miguel

AU - Gelfman, Ruben

AU - Hoischen, Susanne Hildegard

AU - Schön, Staffan

AU - Stroumza, Paul

AU - Timofte, Delia

AU - Török, Marietta

AU - Hegbrant, Jörgen

AU - Wollheim, Charlotta

AU - Frantzen, Luc

AU - Strippoli, G F M

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/3/20

Y1 - 2015/3/20

N2 - INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.METHODS AND ANALYSIS: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

AB - INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.METHODS AND ANALYSIS: DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

UR - http://www.scopus.com/inward/record.url?scp=84926442249&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2014-006897

DO - 10.1136/bmjopen-2014-006897

M3 - Article

VL - 5

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 3

M1 - e006897

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