Novel Therapeutics Targeting Cancer Stem Cell Surface Markers

SMK Gamage; Chamath Ranaweera; Kalana Prasad  Maduwage; Tracie Cheng; Farhadul Islam; Vinod Gopalan

doi:10.1007/978-981-99-3185-9_10

Novel Therapeutics Targeting Cancer Stem Cell Surface Markers

SMK Gamage^*, Chamath Ranaweera, Kalana Prasad Maduwage, Tracie Cheng, Farhadul Islam, Vinod Gopalan

^*Corresponding author for this work

Faculty of Health Sciences & Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Abstract

Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs present within the tumor mass. CSC biomarker-specific targeted therapy has evolved during the past four decades and has shown promise in reducing tumor bulk, discouraging tumor metastasis, and improving sensitivity to chemo-/radiotherapy. The aim of this chapter is to discuss the novel therapeutics targeting CSCs surface markers. CSCs surface marker-targeted therapies in acute myeloid leukemia, hepatocellular cancer, gynecological cancer, non-small cell lung carcinoma, breast cancer, prostate cancer, brain malignancies, bladder cancer, and other malignancies will be discussed in detail. Keywords Surface markers Targeted therapy Breast cancer Brain cancers Blood cancer Gynecological cancer Bladder cancer

Original language	English
Title of host publication	Cancer Stem Cells: Basic Concept and Therapeutic Implications
Editors	Farhadul Islam, Alfred Lam
Publisher	Springer Nature
Chapter	10
Pages	167-198
Number of pages	31
ISBN (Electronic)	9789819931859
ISBN (Print)	9789819931842
DOIs	https://doi.org/10.1007/978-981-99-3185-9_10
Publication status	Published - 27 Jul 2023

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title = "Novel Therapeutics Targeting Cancer Stem Cell Surface Markers",

abstract = "Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs present within the tumor mass. CSC biomarker-specific targeted therapy has evolved during the past four decades and has shown promise in reducing tumor bulk, discouraging tumor metastasis, and improving sensitivity to chemo-/radiotherapy. The aim of this chapter is to discuss the novel therapeutics targeting CSCs surface markers. CSCs surface marker-targeted therapies in acute myeloid leukemia, hepatocellular cancer, gynecological cancer, non-small cell lung carcinoma, breast cancer, prostate cancer, brain malignancies, bladder cancer, and other malignancies will be discussed in detail. Keywords Surface markers Targeted therapy Breast cancer Brain cancers Blood cancer Gynecological cancer Bladder cancer",

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AU - Ranaweera, Chamath

AU - Maduwage, Kalana Prasad

AU - Cheng, Tracie

AU - Islam, Farhadul

AU - Gopalan, Vinod

PY - 2023/7/27

Y1 - 2023/7/27

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AB - Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs present within the tumor mass. CSC biomarker-specific targeted therapy has evolved during the past four decades and has shown promise in reducing tumor bulk, discouraging tumor metastasis, and improving sensitivity to chemo-/radiotherapy. The aim of this chapter is to discuss the novel therapeutics targeting CSCs surface markers. CSCs surface marker-targeted therapies in acute myeloid leukemia, hepatocellular cancer, gynecological cancer, non-small cell lung carcinoma, breast cancer, prostate cancer, brain malignancies, bladder cancer, and other malignancies will be discussed in detail. Keywords Surface markers Targeted therapy Breast cancer Brain cancers Blood cancer Gynecological cancer Bladder cancer

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M3 - Chapter

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BT - Cancer Stem Cells: Basic Concept and Therapeutic Implications

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PB - Springer Nature

ER -

Novel Therapeutics Targeting Cancer Stem Cell Surface Markers

Abstract

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