Novel Therapeutics Targeting Cancer Stem Cell Surface Markers

SMK Gamage*, Chamath Ranaweera, Kalana Prasad Maduwage, Tracie Cheng, Farhadul Islam, Vinod Gopalan

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review


Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs present within the tumor mass. CSC biomarker-specific targeted therapy has evolved during the past four decades and has shown promise in reducing tumor bulk, discouraging tumor metastasis, and improving sensitivity to chemo-/radiotherapy. The aim of this chapter is to discuss the novel therapeutics targeting CSCs surface markers. CSCs surface marker-targeted therapies in acute myeloid leukemia, hepatocellular cancer, gynecological cancer, non-small cell lung carcinoma, breast cancer, prostate cancer, brain malignancies, bladder cancer, and other malignancies will be discussed in detail. Keywords Surface markers Targeted therapy Breast cancer Brain cancers Blood cancer Gynecological cancer Bladder cancer
Original languageEnglish
Title of host publicationCancer Stem Cells: Basic Concept and Therapeutic Implications
EditorsFarhadul Islam, Alfred Lam
PublisherSpringer Nature
Number of pages31
ISBN (Electronic)9789819931859
ISBN (Print)9789819931842
Publication statusPublished - 27 Jul 2023


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