Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor

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Abstract

The main DC subsets in murine spleen arise from BM-derived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin(-)c-kit(lo) hematopoietic progenitor and is most highly enriched among the Lin(-)c-kit(lo)CD34(+) subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8(+) T cells but not CD4(+) T cells.

Original languageEnglish
Pages (from-to)63-9
Number of pages7
JournalJournal of Leukocyte Biology
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

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