Novel nutritional substrates in surgery

Nikki Buijs, Elisabeth A Wörner, Saskia J H Brinkmann, Joanna Luttikhold, Barbara S van der Meij, Alexander P J Houdijk, Paul A M van Leeuwen

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Pharmaco-nutrients have beneficial effects on protective and immunological mechanisms in patients undergoing surgery, which are important for recovery after injury and in combating infectious agents. The aim of this review article was to outline the potential of the administration of nutritional substrates to surgical patients and the underlying mechanisms that make them particularly important in peri-operative care. Surgery causes a stress response, which has catabolic effects on the body's substrate stores. The amino acid glutamine is a stimulating agent for immune cells. It activates protective mechanisms through its role as a precursor for antioxidants and it improves the barrier function of the gut. Arginine also enhances the function of the immune system, since it is the substrate for T-lymphocytes. Furthermore, n-3 PUFA stabilise surgery-induced hyper-inflammation. Taurine is another substrate that may counteract the negative effects of surgical injury on acid-base balance and osmotic balance. These pharmaco-nutrients rapidly become deficient under the influence of surgical stress. Supplementation of these nutrients in surgical patients may restore their protective and immune-enhancing actions and improve clinical outcome. Moreover, pre-operative fasting is still common practice in the Western world, although fasting has a negative effect on the patient's condition and the recovery after surgery. This may be counteracted by a simple intervention such as administering a carbohydrate-rich supplement just before surgery. In conclusion, there are various nutritional substrates that may be of great value in improving the condition of the surgical patient, which may be beneficial for post-operative recovery.

Original languageEnglish
Pages (from-to)277-87
Number of pages11
JournalProceedings of the Nutrition Society
Volume72
Issue number3
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

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Food
Fasting
Western World
Acid-Base Equilibrium
Taurine
Intraoperative Complications
Omega-3 Fatty Acids
Glutamine
Arginine
Immune System
Antioxidants
Carbohydrates
Inflammation
T-Lymphocytes
Amino Acids
Wounds and Injuries

Cite this

Buijs, N., Wörner, E. A., Brinkmann, S. J. H., Luttikhold, J., van der Meij, B. S., Houdijk, A. P. J., & van Leeuwen, P. A. M. (2013). Novel nutritional substrates in surgery. Proceedings of the Nutrition Society, 72(3), 277-87. https://doi.org/10.1017/S0029665112003047
Buijs, Nikki ; Wörner, Elisabeth A ; Brinkmann, Saskia J H ; Luttikhold, Joanna ; van der Meij, Barbara S ; Houdijk, Alexander P J ; van Leeuwen, Paul A M. / Novel nutritional substrates in surgery. In: Proceedings of the Nutrition Society. 2013 ; Vol. 72, No. 3. pp. 277-87.
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Buijs, N, Wörner, EA, Brinkmann, SJH, Luttikhold, J, van der Meij, BS, Houdijk, APJ & van Leeuwen, PAM 2013, 'Novel nutritional substrates in surgery' Proceedings of the Nutrition Society, vol. 72, no. 3, pp. 277-87. https://doi.org/10.1017/S0029665112003047

Novel nutritional substrates in surgery. / Buijs, Nikki; Wörner, Elisabeth A; Brinkmann, Saskia J H; Luttikhold, Joanna; van der Meij, Barbara S; Houdijk, Alexander P J; van Leeuwen, Paul A M.

In: Proceedings of the Nutrition Society, Vol. 72, No. 3, 08.2013, p. 277-87.

Research output: Contribution to journalArticleResearchpeer-review

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Buijs N, Wörner EA, Brinkmann SJH, Luttikhold J, van der Meij BS, Houdijk APJ et al. Novel nutritional substrates in surgery. Proceedings of the Nutrition Society. 2013 Aug;72(3):277-87. https://doi.org/10.1017/S0029665112003047