Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

Claudio Pizzolato; Dinesh B. Palipana; Kyle Mulholland; Alastair R.J. Quinn; Malik M.N. Mannan; Kelly Clanchy; Claire B. Crossley; Evan Jurd; Surendran Sabapathy; Leanne Bisset; Ewan C.R. Lloyd; Belinda Beck; Ana C.C. de Sousa; Yang D. Teng; David G. Lloyd

doi:10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

Claudio Pizzolato^*, Dinesh B. Palipana, Kyle Mulholland, Alastair R.J. Quinn, Malik M.N. Mannan, Kelly Clanchy, Claire B. Crossley, Evan Jurd, Surendran Sabapathy, Leanne Bisset, Ewan C.R. Lloyd, Belinda Beck, Ana C.C. de Sousa, Yang D. Teng, David G. Lloyd

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

Abstract

Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.

Original language	English
Title of host publication	Converging Clinical and Engineering Research on Neurorehabilitation V
Publisher	Springer
Pages	63-67
Number of pages	5
ISBN (Print)	9783031775833
DOIs	https://doi.org/10.1007/978-3-031-77584-0_13
Publication status	Published - 2024
Externally published	Yes
Event	6th International Conference on Neurorehabilitation - La Granja, Spain Duration: 5 Nov 2024 → 8 Nov 2024 https://2024.icneurorehab.org/

Publication series

Name	Biosystems and Biorobotics
Volume	32
ISSN (Print)	2195-3562
ISSN (Electronic)	2195-3570

Conference

Conference	6th International Conference on Neurorehabilitation
Abbreviated title	ICNR 2024
Country/Territory	Spain
City	La Granja
Period	5/11/24 → 8/11/24
Internet address	https://2024.icneurorehab.org/

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10.1007/978-3-031-77584-0_13

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Pizzolato, C., Palipana, D. B., Mulholland, K., Quinn, A. R. J., Mannan, M. M. N., Clanchy, K., Crossley, C. B., Jurd, E., Sabapathy, S., Bisset, L., Lloyd, E. C. R., Beck, B., de Sousa, A. C. C., Teng, Y. D., & Lloyd, D. G. (2024). Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. In Converging Clinical and Engineering Research on Neurorehabilitation V (pp. 63-67). (Biosystems and Biorobotics; Vol. 32). Springer. https://doi.org/10.1007/978-3-031-77584-0_13

@inproceedings{efda81f3d63f4b6ba245735fe864dddd,

title = "Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury",

abstract = "Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.",

author = "Claudio Pizzolato and Palipana, {Dinesh B.} and Kyle Mulholland and Quinn, {Alastair R.J.} and Mannan, {Malik M.N.} and Kelly Clanchy and Crossley, {Claire B.} and Evan Jurd and Surendran Sabapathy and Leanne Bisset and Lloyd, {Ewan C.R.} and Belinda Beck and {de Sousa}, {Ana C.C.} and Teng, {Yang D.} and Lloyd, {David G.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.; 6th International Conference on Neurorehabilitation, ICNR 2024 ; Conference date: 05-11-2024 Through 08-11-2024",

year = "2024",

doi = "10.1007/978-3-031-77584-0_13",

language = "English",

isbn = "9783031775833",

series = "Biosystems and Biorobotics",

publisher = "Springer",

pages = "63--67",

booktitle = "Converging Clinical and Engineering Research on Neurorehabilitation V",

address = "Germany",

url = "https://2024.icneurorehab.org/",

}

Pizzolato, C, Palipana, DB, Mulholland, K, Quinn, ARJ, Mannan, MMN, Clanchy, K, Crossley, CB, Jurd, E, Sabapathy, S, Bisset, L, Lloyd, ECR, Beck, B, de Sousa, ACC, Teng, YD & Lloyd, DG 2024, Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. in Converging Clinical and Engineering Research on Neurorehabilitation V. Biosystems and Biorobotics, vol. 32, Springer, pp. 63-67, 6th International Conference on Neurorehabilitation, La Granja, Spain, 5/11/24. https://doi.org/10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. / Pizzolato, Claudio; Palipana, Dinesh B.; Mulholland, Kyle et al.
Converging Clinical and Engineering Research on Neurorehabilitation V. Springer, 2024. p. 63-67 (Biosystems and Biorobotics; Vol. 32).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

TY - GEN

T1 - Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

AU - Pizzolato, Claudio

AU - Palipana, Dinesh B.

AU - Mulholland, Kyle

AU - Quinn, Alastair R.J.

AU - Mannan, Malik M.N.

AU - Clanchy, Kelly

AU - Crossley, Claire B.

AU - Jurd, Evan

AU - Sabapathy, Surendran

AU - Bisset, Leanne

AU - Lloyd, Ewan C.R.

AU - Beck, Belinda

AU - de Sousa, Ana C.C.

AU - Teng, Yang D.

AU - Lloyd, David G.

PY - 2024

Y1 - 2024

N2 - Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.

AB - Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.

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UR - https://2024.icneurorehab.org/

U2 - 10.1007/978-3-031-77584-0_13

DO - 10.1007/978-3-031-77584-0_13

M3 - Conference contribution

AN - SCOPUS:85214030500

SN - 9783031775833

T3 - Biosystems and Biorobotics

SP - 63

EP - 67

BT - Converging Clinical and Engineering Research on Neurorehabilitation V

PB - Springer

T2 - 6th International Conference on Neurorehabilitation

Y2 - 5 November 2024 through 8 November 2024

ER -

Pizzolato C, Palipana DB, Mulholland K, Quinn ARJ, Mannan MMN, Clanchy K et al. Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. In Converging Clinical and Engineering Research on Neurorehabilitation V. Springer. 2024. p. 63-67. (Biosystems and Biorobotics). doi: 10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

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