Niches for extramedullary hematopoiesis in spleen

Research output: Contribution to journalArticleResearch

Abstract

The spleen is a major site for extramedullary hematopoiesis and adult mouse and human spleens retain low numbers of hematopoietic stem cells (HSC). Hematopoiesis is however dependent on stromal microenvironments that provide
appropriate molecular signals. Recent evidence now suggests that a distinct stromal cell type exists in the spleen which can function as a niche for hematopoiesis. This review considers the role of the spleen in hematopoiesis, and the possibility
that the spleen can be utilized or amplified as a site for hematopoiesis during HSC transplantation. If stromal cells can be isolated and used to expand HSC in vitro, or provided as an ectopic niche in vivo for the same purpose, then
the potential exists to enhance hematopoiesis in patients undergoing myeloablative treatment, HSC transplantation or involution of lymphoid tissue with ageing.
Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalNiche
Volume1
Issue number1
Publication statusPublished - 2012
Externally publishedYes

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Extramedullary Hematopoiesis
Hematopoiesis
Spleen
Hematopoietic Stem Cell Transplantation
Stromal Cells
Hematopoietic Stem Cells
Lymphoid Tissue

Cite this

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title = "Niches for extramedullary hematopoiesis in spleen",
abstract = "The spleen is a major site for extramedullary hematopoiesis and adult mouse and human spleens retain low numbers of hematopoietic stem cells (HSC). Hematopoiesis is however dependent on stromal microenvironments that provideappropriate molecular signals. Recent evidence now suggests that a distinct stromal cell type exists in the spleen which can function as a niche for hematopoiesis. This review considers the role of the spleen in hematopoiesis, and the possibilitythat the spleen can be utilized or amplified as a site for hematopoiesis during HSC transplantation. If stromal cells can be isolated and used to expand HSC in vitro, or provided as an ectopic niche in vivo for the same purpose, thenthe potential exists to enhance hematopoiesis in patients undergoing myeloablative treatment, HSC transplantation or involution of lymphoid tissue with ageing.",
author = "Helen O'Neill",
year = "2012",
language = "English",
volume = "1",
pages = "12--16",
journal = "Niche",
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Niches for extramedullary hematopoiesis in spleen. / O'Neill, Helen.

In: Niche, Vol. 1, No. 1, 2012, p. 12-16.

Research output: Contribution to journalArticleResearch

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T1 - Niches for extramedullary hematopoiesis in spleen

AU - O'Neill, Helen

PY - 2012

Y1 - 2012

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AB - The spleen is a major site for extramedullary hematopoiesis and adult mouse and human spleens retain low numbers of hematopoietic stem cells (HSC). Hematopoiesis is however dependent on stromal microenvironments that provideappropriate molecular signals. Recent evidence now suggests that a distinct stromal cell type exists in the spleen which can function as a niche for hematopoiesis. This review considers the role of the spleen in hematopoiesis, and the possibilitythat the spleen can be utilized or amplified as a site for hematopoiesis during HSC transplantation. If stromal cells can be isolated and used to expand HSC in vitro, or provided as an ectopic niche in vivo for the same purpose, thenthe potential exists to enhance hematopoiesis in patients undergoing myeloablative treatment, HSC transplantation or involution of lymphoid tissue with ageing.

UR - https://openresearch-repository.anu.edu.au/handle/1885/10577

M3 - Article

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EP - 16

JO - Niche

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