Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain

J. Ekberg, David J. Adams

Research output: Contribution to journalShort surveyResearchpeer-review

39 Citations (Scopus)

Abstract

Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.

Original languageEnglish
Pages (from-to)2005-2010
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number12
DOIs
Publication statusPublished - 2006
Externally publishedYes

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