Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain

J. Ekberg; David J. Adams

doi:10.1016/j.biocel.2006.06.008

Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain

J. Ekberg, David J. Adams

Research output: Contribution to journal › Short survey › Research › peer-review

50 Citations (Scopus)

Abstract

Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.

Original language	English
Pages (from-to)	2005-2010
Number of pages	6
Journal	International Journal of Biochemistry and Cell Biology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/j.biocel.2006.06.008
Publication status	Published - 2006
Externally published	Yes

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10.1016/j.biocel.2006.06.008

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abstract = "Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.",

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AB - Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification and membrane insertion and retrieval. Multiple VGSC subtypes exist that vary in their biophysical and pharmacological properties and tissue distribution. Any alteration of the VGSC subtype profile of a neuron or the mechanisms that regulate VGSC activity can cause significant changes in neuronal excitability. Inflammatory and neuropathic pain states are characterised by alterations in VGSC subtype composition and activity in sensory neurons. This review focuses on the VGSC subtypes involved in such pain states.

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JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

IS - 12

ER -

Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain

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