In their Comment (Aug 2, p 386),1 Jonathan Nguyen-Van-Tam and colleagues suggest that findings from our Cochrane review2 and a study of observational data3 are consistent. In our review, which was based on full clinical study reports of all manufacturer-sponsored randomised trials, we did not find evidence that neuraminidase inhibitors improve important outcomes of influenza, whereas the Roche-funded individual analysis of a subset of retrospective case reports suggested that neuraminidase inhibitors do have some beneficial effect.
Del Mar, C., Doshi, P., Hama, R., Jones, M., Jefferson, T., Heneghan, C., ... Howick, J. (2014). Neuraminidase inhibitors for influenza complications. The Lancet, 384(9950), 1260-1261. https://doi.org/10.1016/S0140-6736(14)61761-X