This chapter reviews and gives pointers to major computational models of serotonergic systems at the level of microcircuits in the cortex and brain stem; and broadly for cognitive and decision making networks.
The Serotonergic System
The mammalian dorsal raphe nucleus (DRN), one of the raphe nuclei in the brain stem, contains the majority of forebrain- projecting 5-HT neurons (Azmitia & Segal, 1978; Descarries, Alain, & Watkins, 1975; Jacobs & Azmitia, 1992; Moore, Halaris, & Jones, 1978; Vertes, 1991). Serotonin receptors are widely spread around the basal ganglia (BG) and the cortex, which are the key areas involved in decision making. Seven major receptor families have been identified for 5-HT, labeled as 5-HT1 to 5-HT7 (Bradley et al., 1986).
|Title of host publication||Computational Models of Brain and Behavior|
|Publication status||Published - 2018|