Natural killer cells in patients with severe chronic fatigue syndrome

E. W. Brenu, S. L. Hardcastle, G. M. Atkinson, M. L. van Driel, S. Kreijkamp-Kaspers, K. J. Ashton, D. R. Staines, S. M. Marshall-Gradisnik

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalAutoimmunity Highlights
Volume4
Issue number3
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Chronic Fatigue Syndrome
Natural Killer Cells
Virus Diseases
Autoimmune Diseases
Immune System
Immunity
Homeostasis
Transcription Factors
Apoptosis
Cytokines
Health
Neoplasms
Proteins

Cite this

Brenu, E. W., Hardcastle, S. L., Atkinson, G. M., van Driel, M. L., Kreijkamp-Kaspers, S., Ashton, K. J., ... Marshall-Gradisnik, S. M. (2013). Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmunity Highlights, 4(3), 69-80. https://doi.org/10.1007/s13317-013-0051-x
Brenu, E. W. ; Hardcastle, S. L. ; Atkinson, G. M. ; van Driel, M. L. ; Kreijkamp-Kaspers, S. ; Ashton, K. J. ; Staines, D. R. ; Marshall-Gradisnik, S. M. / Natural killer cells in patients with severe chronic fatigue syndrome. In: Autoimmunity Highlights. 2013 ; Vol. 4, No. 3. pp. 69-80.
@article{da707644ac554c14a303415e746a8270,
title = "Natural killer cells in patients with severe chronic fatigue syndrome",
abstract = "Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.",
author = "Brenu, {E. W.} and Hardcastle, {S. L.} and Atkinson, {G. M.} and {van Driel}, {M. L.} and S. Kreijkamp-Kaspers and Ashton, {K. J.} and Staines, {D. R.} and Marshall-Gradisnik, {S. M.}",
year = "2013",
month = "12",
doi = "10.1007/s13317-013-0051-x",
language = "English",
volume = "4",
pages = "69--80",
journal = "Autoimmunity Highlights",
issn = "2038-0305",
publisher = "Springer-Verlag London Ltd.",
number = "3",

}

Brenu, EW, Hardcastle, SL, Atkinson, GM, van Driel, ML, Kreijkamp-Kaspers, S, Ashton, KJ, Staines, DR & Marshall-Gradisnik, SM 2013, 'Natural killer cells in patients with severe chronic fatigue syndrome' Autoimmunity Highlights, vol. 4, no. 3, pp. 69-80. https://doi.org/10.1007/s13317-013-0051-x

Natural killer cells in patients with severe chronic fatigue syndrome. / Brenu, E. W.; Hardcastle, S. L.; Atkinson, G. M.; van Driel, M. L.; Kreijkamp-Kaspers, S.; Ashton, K. J.; Staines, D. R.; Marshall-Gradisnik, S. M.

In: Autoimmunity Highlights, Vol. 4, No. 3, 12.2013, p. 69-80.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Natural killer cells in patients with severe chronic fatigue syndrome

AU - Brenu, E. W.

AU - Hardcastle, S. L.

AU - Atkinson, G. M.

AU - van Driel, M. L.

AU - Kreijkamp-Kaspers, S.

AU - Ashton, K. J.

AU - Staines, D. R.

AU - Marshall-Gradisnik, S. M.

PY - 2013/12

Y1 - 2013/12

N2 - Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.

AB - Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence of pathogens and tumour cells activates innate immune cells, in particular Natural Killer (NK) cells. Stochastic expression of NK receptors activates either inhibitory or activating signals and results in cytokine production and activation of pathways that result in apoptosis of target cells. Thus, NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS). The purpose of this review is to highlight the different profiles of NK cells reported in CFS patients and to determine the extent of NK immune dysfunction in subtypes of CFS patients based on severity in symptoms.

UR - http://www.scopus.com/inward/record.url?scp=84888264788&partnerID=8YFLogxK

U2 - 10.1007/s13317-013-0051-x

DO - 10.1007/s13317-013-0051-x

M3 - Article

VL - 4

SP - 69

EP - 80

JO - Autoimmunity Highlights

JF - Autoimmunity Highlights

SN - 2038-0305

IS - 3

ER -

Brenu EW, Hardcastle SL, Atkinson GM, van Driel ML, Kreijkamp-Kaspers S, Ashton KJ et al. Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmunity Highlights. 2013 Dec;4(3):69-80. https://doi.org/10.1007/s13317-013-0051-x