Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function

Ying Y Hey, Helen C O'Neill

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29 Citations (Scopus)


The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.

Original languageEnglish
Pages (from-to)2611-9
Number of pages9
JournalJournal of Cellular and Molecular Medicine
Issue number11
Publication statusPublished - Nov 2012
Externally publishedYes


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