Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function

Ying Y Hey, Helen C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.

Original languageEnglish
Pages (from-to)2611-9
Number of pages9
JournalJournal of Cellular and Molecular Medicine
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

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Myeloid Cells
Dendritic Cells
Spleen
Antigens
Antigen Presentation
Adaptive Immunity
Antigen-Presenting Cells
Immunity
T-Lymphocytes
Phenotype
Population

Cite this

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Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function. / Hey, Ying Y; O'Neill, Helen C.

In: Journal of Cellular and Molecular Medicine, Vol. 16, No. 11, 11.2012, p. 2611-9.

Research output: Contribution to journalArticleResearchpeer-review

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