TY - JOUR
T1 - Multiscale models of pharmacological, immunological and neurostimulation treatments in Alzheimer's disease
AU - Cutsuridis, Vassilis
AU - Moustafa, Ahmed A.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The current study reviews computational models that embody a hypothesis and/or a theory of mechanisms of how AD impacts the brain and cognition as well as provide a critical analysis of strengths and weaknesses of these models. Existing models assume AD symptoms stem from abnormalities to cell structure, synaptic connections, neuro-chemicals, as well as other neural circuits and systems. We also discuss how mathematical formulation of the known biology of AD can help us understand AD symptoms and how pharmacological medications and neurostimulation therapies may work. Finally, we discuss general research directions that may improve future treatments of the disease.
AB - The current study reviews computational models that embody a hypothesis and/or a theory of mechanisms of how AD impacts the brain and cognition as well as provide a critical analysis of strengths and weaknesses of these models. Existing models assume AD symptoms stem from abnormalities to cell structure, synaptic connections, neuro-chemicals, as well as other neural circuits and systems. We also discuss how mathematical formulation of the known biology of AD can help us understand AD symptoms and how pharmacological medications and neurostimulation therapies may work. Finally, we discuss general research directions that may improve future treatments of the disease.
UR - http://www.scopus.com/inward/record.url?scp=85008449870&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2016.12.001
DO - 10.1016/j.ddmod.2016.12.001
M3 - Article
AN - SCOPUS:85008449870
SN - 1740-6757
VL - 19
SP - 85
EP - 91
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
ER -