mTOR function in skeletal muscle: A focal point for overnutrition and exercise

Donato A. Rivas, Sarah J. Lessard, Vernon G. Coffey*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

23 Citations (Scopus)

Abstract

The mammalian target of rapamycin (mTOR) is a highly conserved atypical serine-threonine kinase that controls numerous functions essential for cell homeostasis and adaptation in mammalian cells via 2 distinct protein complex formations. Moreover, mTOR is a key regulatory protein in the insulin signalling cascade and has also been characterized as an insulin-independent nutrient sensor that may represent a critical mediator in obesity-related impairments of insulin action in skeletal muscle. Exercise characterizes a remedial modality that enhances mTOR activity and subsequently promotes beneficial metabolic adaptation in skeletal muscle. Thus, the metabolic effects of nutrients and exercise have the capacity to converge at the mTOR protein complexes and subsequently modify mTOR function. Accordingly, the aim of the present review is to highlight the role of mTOR in the regulation of insulin action in response to overnutrition and the capacity for exercise to enhance mTOR activity in skeletal muscle.

Original languageEnglish
Pages (from-to)807-816
Number of pages10
JournalApplied Physiology, Nutrition and Metabolism
Volume34
Issue number5
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

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